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  4. STEAP2 Recombinant Monoclonal Antibody

STEAP2 Recombinant Monoclonal Antibody

  • 中文名稱：
    STEAP2 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA854119MA1HU
  • 規格：
    ￥1320
  • 圖片：
    • Overlay Peak curve showing PC-3 cells stained with CSB-RA854119MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was Fluorescein (FITC) AffiniPure Goat Anti-Human IgG, Fcγ fragment specific at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG1 (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    4921538B17Rik antibody; AI930049 antibody; IPCA 1 antibody; IPCA1 antibody; Metalloreductase STEAP2 antibody; PCANAP 1 antibody; PCANAP1 antibody; Prostate cancer associated protein 1 antibody; Prostate cancer-associated protein 1 antibody; Protein up regulated in metastatic prostate cancer antibody; Protein upregulated in metastatic prostate cancer antibody; PUMPCn antibody; Six transmembrane epithelial antigen of prostate 2 antibody; Six transmembrane epithelial antigen of the prostate 2 antibody; Six-transmembrane epithelial antigen of prostate 2 antibody; SixTransMembrane protein of prostate 1 antibody; STAMP 1 antibody; STAMP1 antibody; STEA2_HUMAN antibody; STEAP 2 antibody; STEAP family member 2; metalloreductase antibody; Steap2 antibody; STMP antibody; UNQ6507/PRO23203 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human STEAP2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6B3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
  • 基因功能參考文獻：
    1. Over-expression of STEAP2 is associated with prostate cancer progression. PMID: 25248617
    2. Data suggest that STAMP1 is required for prostate cancer growth. PMID: 20587517
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    4. cloning and characterization of STAMP1, which is expressed in both normal prostate and prostate neoplasms PMID: 12095985
    5. STEAP2 is involved in the development of prostate cancer. As a cell-surface antigen, it is a potential diagnostic or therapeutic target in prostate cancer. PMID: 12429817
    6. Expression of STAMP2, a gene highly similar to STAMP1 (STEAP2), in prostate cancer cells significantly increases cell growth and colony formation suggesting that STAMP2 may have a role in cell proliferation. PMID: 15897894
    7. STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice. PMID: 19196137
    8. The murine ortholog, Steap2, is a ferrireductase, cupric reductase, and stimulates cellular uptake of both iron and copper in vitro. PMID: 16609065

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  • 亞細胞定位：
    Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    STEAP family
  • 組織特異性：
    Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
  • 數據庫鏈接：

    HGNC: 17885

    OMIM: 605094

    KEGG: hsa:261729

    STRING: 9606.ENSP00000287908

    UniGene: Hs.489051