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  4. SRSF6 Recombinant Monoclonal Antibody

SRSF6 Recombinant Monoclonal Antibody

  • 中文名稱：
    SRSF6 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA075256A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of SR protein repeat expression in HepG2 cells using SR protein repeat antibody. Green, isotype control; red, SR protein repeat.
    • Immunocytochemical staining of HepG2 cells with SR protein repeat antibody. Nuclei were stained blue with DAPI; SR protein repeat was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
    • Western blotting analysis using SR protein repeat antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with SR protein repeat antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SRSF6
  • 別名：
    SRSF6; Serine And Arginine Rich Splicing Factor 6; SRP55; Serine/Arginine-Rich Splicing Factor 6; SFRS6; B52; Splicing Factor, Arginine/Serine-Rich 6; Pre-MRNA-Splicing Factor SRP55; SR Splicing Factor 6; Splicing Factor, Arginine/Serine-Rich, 55 KDa; Epididymis Secretory Protein Li 91; Pre-MRNA Splicing Factor SRP55; HEL-S-91
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human SRSF6 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    9F1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.
  • 基因功能參考文獻：
    1. Data suggest that regulation of pancreatic beta-cell function and survival/apoptosis involves alternative splicing modulated by key splicing regulator SRP55; SRP55-regulated alternative splicing includes modulation of function of pro-apoptotic proteins (BIM, BAX), JNK signaling, and endoplasmic reticulum stress. (BIM = BCL-2 interacting protein BIM; BAX = apoptosis regulator BAX) PMID: 29246973
    2. The recent studies suggest that correcting the SRSF6-driven missplicing and/or microtubule-associated imbalance might be of therapeutic value in Huntington's disease. PMID: 27529534
    3. LINC01133 inhibits epithelial mesenchymal transformation and metastasis in colorectal neoplasms by directly binding to SRSF6 as a target mimic. PMID: 27443606
    4. SRSF6 is a regulator of wound healing and tissue homeostasis in skin. PMID: 24440982
    5. Zinc inhibits the activity of SRSF6 and promotes elimination of exon 4, leading to preferential generation of BimS. PMID: 23648111
    6. The splicing factor SRSF6 is an oncoprotein that regulates the proliferation and survival of lung and colon cancer cells. PMID: 23132731
    7. Phosphorylation of SRp55 by Dyrk1A suppressed its ability to promote Tau exon 10 inclusion. PMID: 22767602
    8. Report upregulation of Bim and the splicing factor SRp55 in melanoma cells from patients treated with selective BRAF inhibitors. PMID: 22516966
    9. SRp55 aids in the generation of partially spliced and unspliced HIV-1 mRNAs. PMID: 21345357
    10. interacts with calcitonin/CGRP exon 4 exonic splice enhancer(ESE); binding of SRp55 to an ESE required for calcitonin mRNA splicing suggests that the different levels of SRp55 in different cell types may regulate calcitonin/CGRP alternative splicing PMID: 12531473
    11. SRp55 binding to a suboptimal RNA binding site in the calcitonin/CGRP pre-mRNA exonic splice enhancer, or increasing the amount of SRp55 in cells, is required for calcitonin mRNA production. PMID: 12549914
    12. Higher relative expression of SR55 protein in breast tumors was associated with altered pattern of CD44 variants incorporating exon v7 PMID: 12779084
    13. These findings show that modulation of splicing activity in p53-deficient cells during the early response to sub-lethal DNA damage results in a change in the splicing of target genes, thus modifying the cellular response to genotoxic agents. PMID: 18571879

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  • 亞細胞定位：
    Nucleus. Nucleus speckle.
  • 蛋白家族：
    Splicing factor SR family
  • 數據庫鏈接：

    HGNC: 10788

    OMIM: 601944

    KEGG: hsa:6431

    STRING: 9606.ENSP00000244020

    UniGene: Hs.684950



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