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  4. RAB5C Recombinant Monoclonal Antibody

RAB5C Recombinant Monoclonal Antibody

  • 中文名稱：
    RAB5C Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA903569A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of RAB5C expression in HepG2 cells using RAB5C antibody. Green, isotype control; red, RAB5C.
    • Immunocytochemical staining of HepG2 cells with RAB5C antibody. Nuclei were stained blue with DAPI; RAB5C was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
    • Western blotting analysis using RAB5C antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with RAB5C antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    RAB5C; RAB5C, Member RAS Oncogene Family; RAB5CL; RABL; RAB5C, Member Of RAS Oncogene Family; Ras-Related Protein Rab-5C; L1880; RAB5L; RAB, Member Of RAS Oncogene Family-Like; EC 3.6.5.2
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human RAB5C protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    12D6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Protein transport. Probably involved in vesicular traffic.
  • 基因功能參考文獻：
    1. We identify RAB5C as a new candidate gene for type-2 diabetes risk with a functional role in endosomal type-2 diabetes module. Functional analysis shows that RAB5C is tyrosine phosphorylated. Data analysis reveals a tyrosine phosphorylation motif in the GTP binding site of RAB5C which may be targeted by insulin receptor. Insulin-dependent tyrosine phosphorylation of RAB5C is inhibited by overexpression of HACD3 (PTPLAD1). PMID: 30300385
    2. Enforced miR-509 expression in NALM6 cells reduced RAB5C mRNA and protein levels, and RAB5C was demonstrated to be a direct target of miR-509. PMID: 25368993
    3. PLP2 and RAB5C are binding partners of TPD52. PMID: 24604726
    4. Rab5C modulates Rac1-mediated cell motility. PMID: 24587345
    5. GTP-Rab5c also bound to AMAP1, and activation of Rab5c by EGFR signaling was necessary to promote the intracellular association of AMAP1 and PRKD2 PMID: 22734003

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 數據庫鏈接：

    HGNC: 9785

    OMIM: 604037

    KEGG: hsa:5878

    STRING: 9606.ENSP00000345689

    UniGene: Hs.650382