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  4. Phospho-PTS (S19) Recombinant Monoclonal Antibody

Phospho-PTS (S19) Recombinant Monoclonal Antibody

  • 中文名稱：
    Phospho-PTS (S19) Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA871518A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Overlay Peak curve showing HepG2 cells stained with CSB-RA871518A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10, 000 events was performed.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PTS
  • 別名：
    6 pyruvoyl tetrahydrobiopterin synthase antibody; 6 pyruvoyl tetrahydropterin synthase antibody; 6 pyruvoyltetrahydropterin synthase antibody; 6-pyruvoyl tetrahydrobiopterin synthase antibody; EC 4.2.3.12 antibody; FLJ97081 antibody; OTTHUMP00000235385 antibody; PTP synthase antibody; PTPS antibody; PTPS_HUMAN antibody; PTS antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide from human PTS protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    18G10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
  • 基因功能參考文獻(xiàn)：
    1. Severe neurological impairment from BH4 deficiency could be prevented by newborn screening for hyperphenylalaninemia (HPA) and proper metabolic management. PMID: 19830588
    2. A total of 43 mutations were identified in the PTS gene in a screen of East Asian populations, comprising 22 previously reported mutations and 21 new discovered mutations. PMID: 22237589
    3. The mutant characterization of PTPS gene was coincident with other early studies in Chinese. The novel mutation L127F was considered as a pathogenetic mutation and associated with severe clinical phenotype. PMID: 18505119
    4. Our data show that PTPS induction is necessary for optimized BH4 synthesis in cytokine-stimulated human coronary artery endothelial cells and point to IL-1beta as a leading cytokine in this process. PMID: 14551150
    5. Hyperphenylalaninemia may be caused by deficiency of Phe hydroxylase or by deficiency of co-factor BH(4). PMID: 16086286
    6. Human PTS was efficiently expressed in noradrenergic regions but only in a small number of dopaminergic neurons. PMID: 16135092
    7. Expression of PTS was significantly decreased in PD cases. PMID: 17270157
    8. mutational analysis in Chinese hyperphenylalaninemia caused by tetrahydrobiopterin synthesis deficiency PMID: 11438997

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  • 相關(guān)疾病：
    Hyperphenylalaninemia, BH4-deficient, A (HPABH4A)
  • 蛋白家族：
    PTPS family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9689

    OMIM: 261640

    KEGG: hsa:5805

    STRING: 9606.ENSP00000280362

    UniGene: Hs.503860



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