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  4. PPP2R5E Recombinant Monoclonal Antibody

PPP2R5E Recombinant Monoclonal Antibody

  • 中文名稱：
    PPP2R5E Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA939893A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of PPP2R5E expression in HepG2 cells using PPP2R5E antibody. Green, isotype control; red, PPP2R5E.
    • Immunocytochemical staining of HepG2 cells with PPP2R5E antibody. Nuclei were stained blue with DAPI; PPP2R5E was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using PPP2R5E antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with PPP2R5E antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Protein Phosphatase 2 Regulatory Subunit B'Epsilon; B56epsilon; B56E; Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Epsilon Isoform; Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Epsilon; Protein Phosphatase 2, Regulatory Subunit B (B56), Epsilon Isoform; Protein Phosphatase 2 Regulatory Subunit B', Epsilon; PP2A B Subunit Isoform PR61-Epsilon; PP2A B Subunit Isoform B56-Epsilon; PP2A B Subunit Isoform B'-Epsilon; PP2A B Subunit Isoform R5-Epsilon; PP2A, B Subunit, PR61 Epsilon; PP2A, B Subunit, B56 Epsilon; PP2A, B Subunit, B' Epsilon; PP2A, B Subunit, R5 Epsilon
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human PPP2R5E protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    7D2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
  • 基因功能參考文獻：
    1. results suggest that the PPP2R5E phosphatase may contribute to microtubule organization by stabilizing MTCL1. PMID: 27521566
    2. PP2A holoenzyme containing B56 is responsible for the dephosphorylation of gamma-H2AX and regulation of DNA repair of double strand breaks induced by camptothecin. PMID: 25772433
    3. the significance of miR-23a and PPP2R5E in the proliferation and apoptosis of gastric cancer cells PMID: 24997345
    4. Downregulation of PPP2R5E affects the oncogenic potential of leukemic cells. PMID: 23812941
    5. identified the phosphorylation of hSgo2 by Aurora B at the N-terminal coiled-coil region and the middle region, and showed that these phosphorylations separately promote binding of hSgo2 to PP2A and MCAK PMID: 20889715
    6. The PPP2R5E gene is identified as harboring genetic variants that can affect human cancer and are possibly under evolutionary selection pressure. PMID: 19773383

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Phosphatase 2A regulatory subunit B56 family
  • 數據庫鏈接：

    HGNC: 9313

    OMIM: 601647

    KEGG: hsa:5529

    STRING: 9606.ENSP00000337641

    UniGene: Hs.334868