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  4. PPM1G Recombinant Monoclonal Antibody

PPM1G Recombinant Monoclonal Antibody

  • 中文名稱：
    PPM1G Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA246723A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of PPM1G expression in HepG2 cells using PPM1G antibody. Green, isotype control; red, PPM1G.
    • Western blotting analysis using PPM1G antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with PPM1G antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PPM1G
  • 別名：
    PPM1G; Protein Phosphatase, Mg2+/Mn2+ Dependent 1G; PP2CG; Protein Phosphatase Magnesium-Dependent 1 Gamma; Protein Phosphatase 1G ; Protein Phosphatase 1C; EC 3.1.3.16; PP2C-Gamma; PP2CGAMMA; Protein Phosphatase 1G (Formerly 2C), Magnesium-Dependent, Gamma Isoform; Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G; Protein Phosphatase 2C, Gamma Isoform; Protein Phosphatase 2C Isoform Gamma; PP2C, Gamma; PP2Cgamma; PPP2CG; PPM1C
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human PPM1G protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    11C2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 基因功能參考文獻：
    1. PPM1G phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb has been released from the 7SK snRNP. PMID: 26324325
    2. Hypermethylation in the 3'-protein-phosphatase-1G (PPM1G) gene locus was associated with alcohol use disorder. PMID: 25982659
    3. PPM1G inactivates monomeric WWP2 and promotes the assembly of WWP2-WWP1 heterodimeric complex. PMID: 25071155
    4. PPM1G dephosphorylates the P-TEFb kinase T loop to disassemble the 7SK snRNP. PMID: 24316072
    5. study has identified protein phosphatase PPM1G as a novel regulator of cap-dependent protein translation by negatively controlling the phosphorylation of 4E-BP1. PMID: 23814053
    6. ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage PMID: 22361354
    7. The degradation of p21(WAF1/CIP1) induced by PP2Cgamma was mediated in a proteasome-dependent manner. PMID: 17054950
    8. Protein phosphatase 2C gamma mediates histone dephosphorylation/exchange in response to DNA damage or checkpoint recovery in higher eukaryotes. PMID: 17074886
    9. PP2Cgamma modulates alternative splicing of specific pre-mRNAs coregulated by YB-1. PMID: 17572683
    10. an interplay between PPM1G and unrip determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex PMID: 17984321
    11. PP2Cgamma is a novel regulator of p21(Cip1/WAF1) protein stability via the Akt signaling pathway. PMID: 19538940
    12. Functional study of the mouse homolog PMID: 9271424

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  • 亞細胞定位：
    Cytoplasm. Membrane; Lipid-anchor.
  • 蛋白家族：
    PP2C family
  • 組織特異性：
    Widely expressed. Most abundant in testis, skeletal muscle, and heart.
  • 數據庫鏈接：

    HGNC: 9278

    OMIM: 605119

    KEGG: hsa:5496

    STRING: 9606.ENSP00000264714

    UniGene: Hs.643951