国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. PLAA Recombinant Monoclonal Antibody

PLAA Recombinant Monoclonal Antibody

  • 中文名稱：
    PLAA Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA929118A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of phospholipase A2 activating protein expression in HepG2 cells using phospholipase A2 activating protein antibody. Green, isotype control; red, phospholipase A2 activating protein.
    • Immunocytochemical staining of HepG2 cells with Phospholipase A2 activating protein antibody. Nuclei were stained blue with DAPI; Phospholipase A2 activating protein was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using phospholipase A2 activating protein antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with phospholipase A2 activating protein antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    PLAA; Phospholipase A2 Activating Protein; PLA2P; PLAP; DOA1; Phospholipase A-2-Activating Protein; FLJ11281; FLJ12699; DOA1 Homolog (S. Cerevisiae); DOA1 Homolog; NDMSBA
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human PLAA protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    7B9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
  • 基因功能參考文獻：
    1. In both human and mouse, hypomorphic mutations in the ubiquitin adaptor protein PLAA cause an infantile-lethal neurodysfunction syndrome with seizures. PMID: 28413018
    2. This study presented that Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy. PMID: 28007986
    3. This review provides evidence that 1,25-dihydroxy vitamin D3 stimulates PLA2 via PLAA and CaMKII, a process initiated by Pdia3/PLAA interaction, which further triggers CaMKII-dependent PLA2 activation. [review] PMID: 25448737
    4. Function assignment to conserved residues in mammalian alkaline phosphatases. PMID: 11937510
    5. PLAP inhibits sPLA2-triggered release of fatty acids from erythrocyte membranes PMID: 14499668
    6. identified one stimulatory element, with Sp1 binding sites, and one inhibitory element, in exon 1 of the plaa gene PMID: 18291623
    7. Structural basis for ubiquitin recognition by a novel domain from the human phospholipase A2-activating protein PMID: 19423704

    顯示更多

    收起更多

  • 相關疾病：
    Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies (NDMSBA)
  • 亞細胞定位：
    Nucleus. Cytoplasm. Cell junction, synapse.
  • 蛋白家族：
    WD repeat PLAP family
  • 數據庫鏈接：

    HGNC: 9043

    OMIM: 603873

    KEGG: hsa:9373

    STRING: 9606.ENSP00000380460

    UniGene: Hs.27182



主站蜘蛛池模板： 长春市| 台前县| 顺昌县| 宁河县| 阿勒泰市| 石泉县| 南宁市| 荥阳市| 义乌市| 营山县| 苍梧县| 洛隆县| 林周县| 北流市| 满城县| 即墨市| 松江区| 英吉沙县| 昌邑市| 千阳县| 灵山县| 密山市| 美姑县| 沙河市| 旬邑县| 三门县| 镇平县| 南宁市| 漳浦县| 乐昌市| 宁蒗| 宣汉县| 江阴市| 肇东市| 菏泽市| 子长县| 西充县| 黄山市| 巴彦淖尔市| 乐业县| 湟中县|