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PGM1 Recombinant Monoclonal Antibody

  • 中文名稱:
    PGM1 Recombinant Monoclonal Antibody
  • 貨號:
    CSB-RA964397A0HU
  • 規格:
    ¥1320
  • 圖片:
    • Flow cytometric analysis of phosphoglucomutase 1 expression in HepG2 cells using phosphoglucomutase 1 antibody. Green, isotype control; red, phosphoglucomutase 1.
    • Immunocytochemical staining of HepG2 cells with phosphoglucomutase 1 antibody. Nuclei were stained blue with DAPI; Phosphoglucomutase 1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
    • Western blotting analysis using phosphoglucomutase 1? antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with phosphoglucomutase 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PGM1
  • 別名:
    PGM1; Phosphoglucomutase 1; Glucose Phosphomutase 1; Phosphoglucomutase-1; EC 5.4.2.2; PGM 1; EC 5.4.2; CDG1T; GSD14
  • 反應種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human PGM1 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Rabbit IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    16B5
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, FC, ICC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    This enzyme participates in both the breakdown and synthesis of glucose.
  • 基因功能參考文獻:
    1. PGM1 deficiency has been recognized as a cause of the congenital disorders of glycosylation. PMID: 29858906
    2. The structural perturbation resulting from mutation of this single amino acid reveals the molecular mechanism underlying PGM1 deficiency in these missense variants. PMID: 28117557
    3. Homozygous mutation in the PGM1 gene is associated with PGM1 deficiency. PMID: 26768186
    4. analysis of the structural basis of PGM1 enzyme dysfunction in PGM1 deficiency PMID: 26972339
    5. both PGM1 protein misfolding and catalytic impairment may play a role in PGM1 deficiency PMID: 25288802
    6. PGM1 is required for sustained cell growth during nutritional changes PMID: 24952355
    7. Phosphoglucomutase 1 deficiency, previously identified as a glycogenosis, is also a congenital disorder of glycosylation. PMID: 24499211
    8. The analysis involved the data on nine polymorphic codominant loci: HP, GC, TF, PI, PGM1, GLO1, C3, ACP1, and ESD. The loci were selected by significance of differences in genotype frequencies between tuberculosis patients and healthy controls PMID: 12942785
    9. Results report a novel human protein, calphoglin, which activates inorganic pyrophosphatase (IPP) and enhances phosphoglucomutase activity through the activated IPP. PMID: 15522220
    10. During extrauterine life, females carrying the PGM1*2 allele are relatively protected from extreme body mass increase, and during intrauterine life, PGM1*2/*2 homozygotes show a tendency to low body mass increase. PMID: 18091362
    11. There is a correlation between glomerular expression of MCP-1 and PGM1 and worsening renal prognosis in paediatric lupus nephritis. PMID: 18495743
    12. ZASP/Cypher anchors PGM1 to Z-disc under conditions of stress. The impaired binding of PGM1 to ZASP/Cypher might be involved in the pathogenesis of dilated cardiomyopathy. PMID: 19377068

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  • 相關疾病:
    Congenital disorder of glycosylation 1T (CDG1T)
  • 亞細胞定位:
    [Isoform 1]: Cytoplasm.
  • 蛋白家族:
    Phosphohexose mutase family
  • 數據庫鏈接:

    HGNC: 8905

    OMIM: 171900

    KEGG: hsa:5236

    UniGene: Hs.1869



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