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  4. PCYT1A Recombinant Monoclonal Antibody

PCYT1A Recombinant Monoclonal Antibody

  • 中文名稱：
    PCYT1A Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA698402A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of PCYT1A expression in HepG2 cells using PCYT1A antibody. Green, isotype control; red, PCYT1A.
    • Immunocytochemical staining of HepG2 cells with PCYT1A antibody. Nuclei were stained blue with DAPI; PCYT1A was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
    • Immunohistochemistry was performed on paraffin-embedded human sigmoid colon carcinoma using PCYT1A antibody. Antigen retrieval was done in sodium citrate buffer (pH 6.0). DAB was used for detection, with hematoxylin counterstaining. Images were acquired using a Nikon Ci-L Plus microscope (40× objective). Scale bar: 25 μm.
    • Western blotting analysis using PCYT1A antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with PCYT1A antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PCYT1A
  • 別名：
    PCYT1A; Phosphate Cytidylyltransferase 1A, Choline; CTPCT; CCTalpha; PCYT1; CT; Phosphate Cytidylyltransferase 1, Choline, Alpha; CTP:Phosphocholine Cytidylyltransferase-Alpha; Choline-Phosphate Cytidylyltransferase Alpha; CTP:Phosphocholine Cytidylyltransferase A; Choline-Phosphate Cytidylyltransferase A; Phosphorylcholine Transferase Alpha; Phosphorylcholine Transferase A; EC 2.7.7.15 4; CCT-Alpha; CCT A; CT A; Phosphate Cytidylyltransferase 1, Choline, Alpha Isoform; EC 2.7.7; SMDCRD; CCTA; CGL5;CTA
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human PCYT1A protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    2B7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
    IHC 1:100-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.
  • 基因功能參考文獻(xiàn)：
    1. There is no correlation between single PCYT1A rs712012 and PCYT1A rs7639752 polymorphisms and the incidence of intrauterine fetal death. PMID: 28509322
    2. PCYT1A mutations were identified in patients with isolated retinal dystrophy without any skeletal involvement from two Italian families. PMID: 28272537
    3. CCT contributes to phospholipid compositional homeostasis. [Review] PMID: 26165797
    4. PCYT1A-generated phosphatidylcholine has a role in the normal function of white adipose tissue and insulin action PMID: 24889630
    5. We report loss-of-function mutations in PCYT1A as the cause of spondylometaphyseal dysplasia with cone-rod dystrophy. PMID: 24387990
    6. Mutations in PCYT1A cause spondylometaphyseal dysplasia with cone-rod dystrophy PMID: 24387991
    7. N-Methylaspartate induced nitric oxide synthase activation and nuclear factor-kB subunit p65 nuclear translocation in A549 cells were responsible for decreased CTP:phosphocholine cytidylyltransferase A expression PMID: 20661636
    8. Analyses showed genotype effects of PCYT1A genes on spina bifida risk, but did not show evidence of gene-nutrient. interactions. PMID: 17184542

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  • 相關(guān)疾病：
    Spondylometaphyseal dysplasia with cone-rod dystrophy (SMDCRD)
  • 亞細(xì)胞定位：
    Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Endoplasmic reticulum. Nucleus.
  • 蛋白家族：
    Cytidylyltransferase family
  • 組織特異性：
    Brain, placenta, liver, fetal and adult lung.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8754

    OMIM: 123695

    KEGG: hsa:5130

    STRING: 9606.ENSP00000292823

    UniGene: Hs.135997