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NDUFS3 Recombinant Monoclonal Antibody

  • 中文名稱：
    NDUFS3 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA093387A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of NDUFS3 expression in HepG2 cells using NDUFS3 antibody. Green, isotype control; red, NDUFS3.
    • Immunocytochemical staining of HepG2 cells with NDUFS3 antibody. Nuclei were stained blue with DAPI; NDUFS3 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using NDUFS3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with NDUFS3 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    NDUFS3; NADH:Ubiquinone Oxidoreductase Core Subunit S3; NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 3, Mitochondrial; CI-30; NADH Dehydrogenase (Ubiquinone) Fe-S Protein 3, 30kDa (NADH-Coenzyme Q Reductase); NADH-Ubiquinone Oxidoreductase 30 KDa Subunit; Complex I 30kDa Subunit; Complex I-30kD; CI-30kD; NADH Dehydrogenase (Ubiquinone) Fe-S Protein 3 (30kD) (NADH-Coenzyme Q Reductase); NADH Dehydrogenase-Ubiquinone 30 KDa Subunit; EC 1.6.99.5; EC 7.1.1.2; MC1DN8
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human NDUFS3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    23B1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
  • 基因功能參考文獻：
    1. identified a novel Leigh syndrome causing NDUFS3 mutation and expanded the clinical spectrum caused by NDUFS3 mutations in this study. PMID: 30140060
    2. The results suggest that the impaired mitochondrial activity could be due to the broken interaction between DJ-1 and NDUFS3 and that downregulation of DJ-1 in sperm and testes contributes to AS pathogenesis. PMID: 29849492
    3. The NDUFS3 expressed in the temporal cortex in patient with late-onset Alzheimer's disease. PMID: 28242297
    4. High NDUFS3 expression is associated with IgA nephropathy. PMID: 25770168
    5. pH stability of w-t and Leigh syndrome mutant varied at extreme acidic pH. the molten globule like structure of w-t at pH1 was absent in case of the mutant protein. Both the w-t and mutant proteins showed multi-step thermal and Gdn-HCl induced unfolding PMID: 24028823
    6. NDUFS3 is down-regulated in serous ovarian adenocarcinoma PMID: 23446378
    7. Expressions of GRIM-19, NDUFS3, and extracellular matrix elements are correlated with invasive capabilities of breast cancer cell lines. PMID: 23630608
    8. a novel, biomarker potential of a mitochondrial complex I subunit protein, NDUFS3 - as a robust indicator of breast cancer progression and invasiveness as well as of hypoxia/necrosis in clinical specimens of invasive ductal carcinoma, was uncovered. PMID: 21867691
    9. Decreased protein levels of complex I 30-kDa subunit in fetal Down syndrome brains. PMID: 11771736

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  • 亞細胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族：
    Complex I 30 kDa subunit family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7710

    OMIM: 603846

    KEGG: hsa:4722

    STRING: 9606.ENSP00000263774

    UniGene: Hs.502528