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MTA2 Recombinant Monoclonal Antibody

  • 中文名稱：
    MTA2 Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA149420A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of MTA2 expression in HepG2 cells using MTA2 antibody. Green, isotype control; red, MTA2.
    • Immunocytochemical staining of HepG2 cells with MTA2 antibody. Nuclei were stained blue with DAPI; MTA2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and Smart Gain: High. Scale bar, 20 μm.
    • Western blotting analysis using MTA2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with MTA2 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    MTA2
  • 別名：
    Metastasis Associated 1 Family Member 2; MTA1L1; Metastasis Associated Gene Family, Member 2; P53 Target Protein In Deacetylase Complex; Metastasis-Associated Protein?MTA2; Metastasis-Associated 1-Like 1; MTA1-L1 Protein; MTA1-L1; PID; Metastasis -Associated Gene 1-Like 1; Metastasis-Associated Protein 2
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human MTA2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    8A4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
  • 基因功能參考文獻(xiàn)：
    1. This study is the first to demonstrate that SNHG5 is a critical and powerful regulator that is involved in GC progression through trapping MTA2 in the cytosol. PMID: 27065326
    2. Taken together with previous findings this suggests, that MTA-RBBP is a stable complex, with a central role in the initial assembly of the human NuRD complex. PMID: 28179136
    3. These results indicated there might be a tight correlation among MTA2, Ki-67 and hepatocellular carcinoma prognosis PMID: 26722504
    4. MTA2 is a crucial biomarker that is closely related with prognosis of colorectal carcinoma and also a potential molecular target for evaluating the prognosis and treatment of CRC. PMID: 26261611
    5. MTA2 overexpression enhances colony formation and tumor growth of gastric cancer cells, but not plays important role in cancer cell migration and metastasis. IL-11 is one of the downstream effectors of MTA2 in regulating gastric cancer cells growth PMID: 25929737
    6. MTA-2 protein may facilitate the invasive potential of non-small-cell lung cancer cells through the inhibition of the cell adhesion molecule Ep-CAM and E-cadherin, suggesting that it might be a potential therapeutic target in NSCLC. PMID: 25969565
    7. High MTA2 protein and mRNA expression is associated with glioma. PMID: 25048531
    8. MTA2 acts as a central hub for cytoskeletal organization and transcription and provides a link between nuclear and cytoskeletal organization. PMID: 25394532
    9. MTA2 depletion could significantly inhibit human breast cancer cell growth and metastasis, implying that MTA2 might be involved in the progression of breast cancer. PMID: 25081667
    10. Study demonstrates that hBD-3 inhibits the progression of colon cancer in a paracrine fashion through downregulation of MTA2 expression. PMID: 24969834
    11. Mta2 and Tipin cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate. PMID: 24830473
    12. MTA2 knockdown impairs invasion and metastasis of gastric cancer cells. PMID: 24010737
    13. results reveal a novel post-translational regulation of MTA2 by the way of p300-dependent acetylation, which is important for tumor cells growth and migration and provides a potential target for clinical cancer research PMID: 24468085
    14. High expression levels of MTA2 is associated with pancreatic ductal adenocarcinoma. PMID: 23400716
    15. MTA2 is highly expressed in the primary lesions of gastric cancer than that in adjacent non-cancerous tissues, and is closely related with tumor invasion. MTA2 expression is elevated in Sp1 positive gastric cancer. PMID: 23158992
    16. Sertoli cell-specific expression of MTA2 is required for transcriptional regulation of FSHR gene during spermatogenesis. PMID: 23086931
    17. High nuclear MTA2 expression is associated with thymoma. PMID: 22833212
    18. Our data suggested that MTA2 might play roles in both the nucleus and cytoplasm in the progression of NSCLC. PMID: 22585429
    19. The expression of MTA2 had positive correlation with clinical stage and lymph node metastasis. PMID: 20704817
    20. interaction with mCpG-binding domain of MBD2 PMID: 12124384
    21. MTA2 is a repressor of estrogen receptor (ER)alpha activity and that it could represent a new therapeutic target of ERalpha action in human breast tumors PMID: 16645043
    22. Findings indicate a tight correlation between the MTA2 expression level and hepatocellular carcinoma size and differentiation. PMID: 19702911
    23. Deacetylation and functional interactions by the PID/MTA2-associated NuRD complex may represent an important pathway to regulate p53 function. PMID: 11099047

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  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7411

    OMIM: 603947

    KEGG: hsa:9219

    STRING: 9606.ENSP00000278823

    UniGene: Hs.173043