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  4. MDH2 Recombinant Monoclonal Antibody

MDH2 Recombinant Monoclonal Antibody

  • 中文名稱：
    MDH2 Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA164359A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of malate dehydrogenase 2 expression in C2C12 cells using malate dehydrogenase 2 antibody. Green, isotype control; red, malate dehydrogenase 2.
    • Immunocytochemical staining of C2C12 cells with Malate dehydrogenase 2 antibody. Nuclei were stained blue with DAPI; Malate dehydrogenase 2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
    • Western blotting analysis using malate dehydrogenase 2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with malate dehydrogenase 2 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    MDH2
  • 別名：
    MDH2; Malate Dehydrogenase 2; Malate Dehydrogenase 2, NAD (Mitochondrial); Malate Dehydrogenase, Mitochondrial; EC 1.1.1.37; Testicular Tissue Protein Li 120; MGC:3559; EC 1.1.1; EIEE51; DEE51; M-MDH; MOR1; MDH
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human MDH2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    4A2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. these data suggest that MDH2, functioning as an RNA-binding protein, is involved in the posttranscriptional downregulation of SCN1A expression under seizure condition. PMID: 28433711
    2. loss-of-function mutations in MDH2 are also associated with severe neurological clinical presentations in children PMID: 27989324
    3. Data indicate that acetyl-CoA acetyltransferase (ACAT1) and malate dehydrogenase (MDH2) are involved in various drug-resistance-forming mechanisms. PMID: 25639359
    4. Segregation of the mutation with disease and absence of MDH2 in mutated tumors revealed MDH2 as a novel pheochromocytoma/paraganglioma susceptibility gene. PMID: 25766404
    5. L-2-hydroxyglutarate accumulates as a result of a deficiency in FAD-linked L-2-hydroxyglutarate dehydrogenase. mitochondrial L-malate dehydrogenase is responsible for the excretion of L-2-hydroxyglutarate in this condition. PMID: 17603759

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  • 相關(guān)疾病：
    Epileptic encephalopathy, early infantile, 51 (EIEE51)
  • 亞細(xì)胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    LDH/MDH superfamily, MDH type 1 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6971

    OMIM: 154100

    KEGG: hsa:4191

    STRING: 9606.ENSP00000327070

    UniGene: Hs.520967