LY6E Recombinant Monoclonal Antibody
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中文名稱：LY6E Recombinant Monoclonal Antibody
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貨號(hào)：CSB-RA619076MA1HU
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規(guī)格：￥1320
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圖片：
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Immunofluorescence staining of A549 cell with CSB-RA619076MA1HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L). -
The Binding Activity of Human LY6E with Anti-LY6E recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LY6E protein (CSB-MP619076HU) at 2 μg/mL can bind Anti-LY6E recombinant antibody. The EC50 is 2.483-3.282 ng/mL.
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：CSB-RA619076MA1HU LY6E重組單克隆抗體是專為科研實(shí)驗(yàn)設(shè)計(jì)的高特異性檢測工具，靶向淋巴細(xì)胞抗原6復(fù)合物E（LY6E）蛋白。該蛋白作為干擾素刺激基因產(chǎn)物，在固有免疫應(yīng)答中發(fā)揮重要作用，尤其參與調(diào)控病毒入侵及宿主防御機(jī)制。本產(chǎn)品經(jīng)ELISA及免疫熒光（IF）技術(shù)嚴(yán)格驗(yàn)證，在IF實(shí)驗(yàn)中呈現(xiàn)優(yōu)異性能，推薦使用稀釋比為1:50至1:200時(shí)可實(shí)現(xiàn)清晰的靶蛋白定位與低背景信號(hào)，適用于細(xì)胞或組織樣本中LY6E的亞細(xì)胞分布研究。其在病毒感染模型、宿主-病原體互作機(jī)制探索、免疫調(diào)節(jié)通路分析等基礎(chǔ)研究領(lǐng)域具有廣泛應(yīng)用價(jià)值，可為病毒受體功能研究、抗病毒蛋白網(wǎng)絡(luò)解析等實(shí)驗(yàn)提供可靠支持。該重組單克隆抗體具有高親和力與批次間一致性，能夠滿足蛋白質(zhì)相互作用分析、免疫熒光共定位等精細(xì)化實(shí)驗(yàn)需求，為長期科研項(xiàng)目提供穩(wěn)定的檢測保障。
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Uniprot No.：
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基因名：
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別名：LY6E antibody; 9804 antibody; RIGE antibody; SCA2 antibody; TSA1 antibody; Lymphocyte antigen 6E antibody; Ly-6E antibody; Retinoic acid-induced gene E protein antibody; RIG-E antibody; Stem cell antigen 2 antibody; SCA-2 antibody; Thymic shared antigen 1 antibody; TSA-1 antibody
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反應(yīng)種屬：Human
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免疫原：Recombinant Human LY6E protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：mIgG2a
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純化方式：Affinity-chromatography
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克隆號(hào)：29C11
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IF
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推薦稀釋比：
Application Recommended Dilution IF 1:50-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.; (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus. In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E. Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape.
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基因功能參考文獻(xiàn)：
- LY6E belongs to a growing class of interferon-inducible factors that broadly enhance viral infectivity in an interferon-independent manner. PMID: 30190477
- LY6E knockdown by targeted-siRNA inhibited gastric cancer cell survival and proliferation and induced G1-S cell cycle arrest and apoptosis in gastric cancer cells PMID: 29448250
- High LY6E expression is associated with breast cancer. PMID: 27589564
- LY6E overexpression is associated with Breast Cancer Progression, Immune Escape, and Drug Resistance. PMID: 27197181
- LY6E is a positive modulator of HIV-1 infection in primary human peripheral blood mononuclear cells, immortalized CD4+ T lymphoid cells, and macrophages. HIV Long Terminal Repeat-driven HIV-1 gene expression is also enhanced by LY6E, suggesting additional roles of LY6E in HIV-1 replication. PMID: 28130445
- LY6E level of gene expression may serve as good biomarkers for systemic lupus erythematosus diagnosis. PMID: 25344775
- the LY6E pathway in monocytes represents one of negative feedback mechanisms that counterbalance monocyte activation which may serve as a potential target for immune intervention. PMID: 25225669
- This study suggested that a mutation in SCA2 or SCA3/MJD may be one of the genetic causes of Parkinson's disease in china. PMID: 19672991
- Increased expression of the type I interferon-inducible gene, lymphocyte antigen 6 complex locus E, in peripheral blood cells is predictive of lupus activity in a large cohort of Chinese lupus patients. PMID: 18755862
- Two SCA3 and one SCA2 cases have been identified which show autosomal dominant inheritance in Parkinson disease. PMID: 18990604
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亞細(xì)胞定位：Cell membrane; Lipid-anchor, GPI-anchor.
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組織特異性：Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes.
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