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  4. LMNB2 Recombinant Monoclonal Antibody

LMNB2 Recombinant Monoclonal Antibody

  • 中文名稱：
    LMNB2 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA185103A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of lamin B2 expression in HT-1080 cells using lamin B2 antibody. Green, isotype control; red, lamin B2.
    • Immunocytochemical staining of HT-1080 cells with Lamin B2 antibody. Nuclei were stained blue with DAPI; Lamin B2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using lamin B2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with lamin B2 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    LMNB2; Lamin B2; LMN2; Lamin-B2; Epididymis Secretory Sperm Binding Protein; Lamin B3; MCPH27; LAMB2; EPM9
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human LMNB2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    13G2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
  • 基因功能參考文獻：
    1. our studies strongly implicate an overarching role for Lamin B2 in the maintenance of nuclear architecture since loss of Lamin B2 relieves the spatial positional constraints required for maintaining conserved localization of aneuploid chromosome territories in the interphase nucleus. PMID: 26921073
    2. Mutation of the nuclear lamin gene LMNB2 in progressive myoclonus epilepsy with early ataxia. PMID: 25954030
    3. Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform. PMID: 25477337
    4. Treating normal human fibroblasts with farnesyltransferase inhibitors causes the accumulation of unprocessed lamin B2 and lamin A and a decrease in mature lamin B1 PMID: 23475125
    5. Mutation in LMNB2 gene is associated with partial lipodystrophy. PMID: 22768673
    6. Studies indicate that the lamin-binding proteins implicated in laminopathies include lamin B2 and nuclear envelope proteins. PMID: 21400569
    7. These findings indicate that a lamin dimer principally has the freedom for a "combinatorial" head-to-tail association with all types of lamins, a property that might be of significant importance for the assembly of the nuclear lamina. PMID: 20004208
    8. analysis of protein-DNA interactions at the human lamin B2 replication origin PMID: 12902329
    9. The proteins bound in vivo at the LMNB2 replication origin were investigated along the cell cycle. PMID: 12912926
    10. This analysis reveals the modular structure of the lamin B2 origin and supports the idea that sequence elements close to the replication start site play an important role in origin activation. PMID: 15024083
    11. the distinctive ensemble of heterotypic lamin interactions in a particular cell type affects the stability of the lamin polymer PMID: 15284226
    12. the lamin B2 origin adopts a structure partly composed of intramolecular TAT triads PMID: 15611042
    13. lamin B was essential for the formation of the mitotic matrix that tethers a number of spindle assembly factors; propose that lamin B is a structural component of the spindle matrix that promotes microtubule assembly and organization in mitosis PMID: 16543417
    14. Three new rare heterozygous mutations are the first reported for LMNB2 and are the first reported among patients with acquired partial lipodystrophy. PMID: 16826530
    15. human lamin B(2) is indeed synthesized as a longer version than previously reported, because it contains these additional 20 amino acids PMID: 17070523
    16. The human DNA replication origin, located in the lamin B2 gene, interacts with the DNA topoisomerases I and II in a cell cycle-modulated manner. PMID: 17290216

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  • 相關疾病：
    Partial acquired lipodystrophy (APLD); Epilepsy, progressive myoclonic 9 (EPM9)
  • 亞細胞定位：
    Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.
  • 蛋白家族：
    Intermediate filament family
  • 數據庫鏈接：

    HGNC: 6638

    OMIM: 150341

    KEGG: hsa:84823

    STRING: 9606.ENSP00000462730

    UniGene: Hs.538286