国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. LEFTY1/LEFTY2 Recombinant Monoclonal Antibody

LEFTY1/LEFTY2 Recombinant Monoclonal Antibody

  • 中文名稱：
    LEFTY1/LEFTY2 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA233318A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Immunocytochemical staining of HepG2 cells with LEFTY1 + LEFTY2 antibody. Nuclei were stained blue with DAPI; LEFTY1 + LEFTY2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
    • Western blotting analysis using LEFTY1 + LEFTY2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with LEFTY1 + LEFTY2 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    LEFTY1/LEFTY2
  • 別名：
    LEFTY1; Left-Right Determination Factor 1; LEFTYB; LEFTB; Left-Right Determination Factor B; Protein Lefty-1; Protein Lefty-B; Left-Right Determination, Factor B; LEFTY2; Left-Right Determination Factor 2; LEFTYA; LEFTA; TGFB4; EBAF; Endometrial Bleeding-Associated Factor; Left-Right Determination Factor A; Transforming Growth Factor Beta-4; Protein Lefty-2; Protein Lefty-A; TGF-Beta-4; Endometrial Bleeding Associated Factor (Left-Right Determination, Factor A; Transforming Growth Factor Beta Superfamily); Transforming Growth Factor, Beta-4 (Endometrial Bleeding-Associated Factor; LEFTY A)
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human LEFTY1/LEFTY2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    20B3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
  • 基因功能參考文獻(xiàn)：
    1. functional role of LEFTY during progesterone therapy for endometrial carcinoma PMID: 29268772
    2. LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage. PMID: 27404958
    3. LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration. PMID: 27497669
    4. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. PMID: 27606670
    5. Lefty A may account for the tumor suppressive activity of human adult stem cells. PMID: 22469982
    6. Findings suggest that Lefty2 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification. PMID: 21266536
    7. Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation. PMID: 21401636
    8. findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression PMID: 9230066
    9. may provide a crucial signal for endometrial breakdown and bleeding by triggering expression of several matrix metalloproteinases PMID: 12215426
    10. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells PMID: 15308665
    11. Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids. PMID: 15536155
    12. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation. PMID: 17038673

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Left-right axis malformations (LRAM)
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 組織特異性：
    Mesenchymal cells of the endometrial stroma.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3122

    OMIM: 601877

    KEGG: hsa:7044

    STRING: 9606.ENSP00000355785

    UniGene: Hs.520187