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  4. LAP3 Recombinant Monoclonal Antibody

LAP3 Recombinant Monoclonal Antibody

  • 中文名稱：
    LAP3 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA210434A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Immunocytochemical staining of HAP-1 cells with Leucine aminopeptidase 3 antibody. Nuclei were stained blue with DAPI; Leucine aminopeptidase 3 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Flow cytometric analysis of Leucine aminopeptidase 3 expression in HAP-1 cells using Leucine aminopeptidase 3 antibody. Green, isotype control; red, Leucine aminopeptidase 3.
    • Western blotting analysis using Leucine aminopeptidase 3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Leucine aminopeptidase 3 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    LAP3
  • 別名：
    LAP3; Leucine Aminopeptidase 3; LAPEP; Peptidase S; PEPS; LAP; Cysteinylglycine-S-Conjugate Dipeptidase; Cytosol Aminopeptidase; Proline Aminopeptidase; Leucyl Aminopeptidase; Prolyl Aminopeptidase; EC 3.4.11.1; Epididymis Secretory Protein Li 106; EC 3.4.13.23; EC 3.4.11.5; HEL-S-106;?EC 3.4.11;LAP-3
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human LAP3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    3H2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cytolosic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.
  • 基因功能參考文獻：
    1. LAP3 might be a new prognostic factor and be close correlation with glioma cell growth, migration, invasion. PMID: 25453285
    2. our results indicated that up-regulated expression of LAP3 might contribute to the proliferation and metastasis of hepatocellular carcinoma PMID: 25120751
    3. Overexpression of leucine aminopeptidase 3 contributes to malignant development of human esophageal squamous cell carcinoma. PMID: 24477662
    4. results suggest that Lys528 is important for maximal activity of adipocyte-derived LAP by maintaining the appropriate structure of the substrate pocket of the enzyme PMID: 16513116
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase M17 family
  • 數據庫鏈接：

    HGNC: 18449

    OMIM: 170250

    KEGG: hsa:51056

    STRING: 9606.ENSP00000226299

    UniGene: Hs.570791