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  4. KIFAP3 Recombinant Monoclonal Antibody

KIFAP3 Recombinant Monoclonal Antibody

  • 中文名稱：
    KIFAP3 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA984738A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Kinesin associated protein 3 expression in HepG2 cells using Kinesin associated protein 3 antibody. Green, isotype control; red, Kinesin associated protein 3.
    • Western blotting analysis using Kinesin associated protein 3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Kinesin associated protein 3 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    KIFAP3
  • 別名：
    KIFAP3; Kinesin Associated Protein 3; SMAP; KAP3; Kinesin-Associated Protein 3; KAP-1; FLA3; Smg GDS-Associated Protein; KAP-3; Small G Protein GDP Dissociation Stimulator; DJ190I16.1; Smg GDS; Smg-GDS; KIF3AP
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human KIFAP3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    11A12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex.
  • 基因功能參考文獻：
    1. This study does not show an influence of KIFAP3 variants on survival in the studied Swiss and Swedish cohort PMID: 28140676
    2. Common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. PMID: 24838185
    3. The incidence of the motor neuron-predominant amyotrophic lateral sclerosis phenotype in the patients of this cohort supports the hypothesis that the SNP within the KIFAP3 gene is a potential modifier of the amyotrophic lateral sclerosis phenotype PMID: 21659726
    4. Data clearly show that SNP rs1541160 does not modify survival within cohort of 504 Italian ALS cases. PMID: 20566859
    5. Kinesin-2 plays a role in the KDEL-R-/COPI-dependent retrograde transport pathway from the Golgi complex to the ER. PMID: 17113389
    6. KAP3 sequestration by misfolded SOD1 and the inhibition of ChAT transport play a role in the dysfunction of amyotrophic lateral sclerosis. PMID: 19088126
    7. a variant within the KIFAP3 gene that is associated with decreased KIFAP3 expression and increased survival in sporadic ALS was identified. PMID: 19451621

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  • 數(shù)據(jù)庫鏈接：

    HGNC: 17060

    OMIM: 601836

    KEGG: hsa:22920

    STRING: 9606.ENSP00000354560

    UniGene: Hs.433442



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