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  4. KATNA1 Recombinant Monoclonal Antibody

KATNA1 Recombinant Monoclonal Antibody

  • 中文名稱：
    KATNA1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA828655A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of katanin catalytic subunit A1 expression in Hela cells using katanin catalytic subunit A1 antibody. Green, isotype control; red, katanin catalytic subunit A1.
    • Immunocytochemical staining of Hela cells with katanin catalytic subunit A1 antibody. Nuclei were stained blue with DAPI; Katanin catalytic subunit A1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
    • Western blotting analysis using katanin catalytic subunit A1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with katanin catalytic subunit A1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    KATNA1
  • 別名：
    KATNA1; Katanin Catalytic Subunit A1; Katanin P60 (ATPase Containing) Subunit A 1; Katanin P60 ATPase-Containing Subunit A1; Katanin P60 Subunit A1; P60 Katanin; Katanin P60 (ATPase-Containing) Subunit A 1; EC 5.6.1.1; EC 3.6.4.3
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human KATNA1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    10F7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
  • 基因功能參考文獻：
    1. CAMSAP3 precisely coordinates with dynein and katanin to regulate the microtubule detachment process. PMID: 28386021
    2. Katanin Severing and Binding Microtubules Are Inhibited by Tubulin Carboxy Tails PMID: 26682813
    3. analysis of spastin's microtubule-binding properties and comparison with katanin PMID: 23272056
    4. Data propose a model in which spatial rearrangement of the p60 katanin N-terminal domain relative to the C-terminal AAA domain may be important for productive ATP hydrolysis towards MT-severing. PMID: 22325007
    5. Katanin p60 was aberrantly expressed during prostate cancer progression. The elevated katanin p60 expression may contribute to cancer cell metastasis via a stimulatory effect on cell motility. PMID: 21681775
    6. A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization PMID: 20339000

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  • 亞細胞定位：
    Cytoplasm. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    AAA ATPase family, Katanin p60 subunit A1 subfamily
  • 數據庫鏈接：

    HGNC: 6216

    OMIM: 606696

    KEGG: hsa:11104

    STRING: 9606.ENSP00000335106

    UniGene: Hs.450175