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  4. IFT88 Recombinant Monoclonal Antibody

IFT88 Recombinant Monoclonal Antibody

  • 中文名稱：
    IFT88 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA137131A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of intraflagellar transport 88 expression in HeLa cells using intraflagellar transport 88 antibody. Green, isotype control; red, intraflagellar transport 88.
    • Immunocytochemical staining of HeLa cells with Intraflagellar transport 88 antibody. Nuclei were stained blue with DAPI; Intraflagellar transport 88 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using intraflagellar transport 88 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with intraflagellar transport 88 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    IFT88
  • 別名：
    IFT88; Intraflagellar Transport 88; D13S1056E; TG737; TTC10; Recessive Polycystic Kidney Disease Protein Tg737 Homolog; Intraflagellar Transport Protein 88 Homolog; Tetratricopeptide Repeat Protein 10; Tetratricopeptide Repeat Domain 10; TPR Repeat Protein 10; Polaris Homolog; MGC26259; HTg737; Probe HTg737 (Polycystic Kidney Disease, Autosomal Recessive); Intraflagellar Transport 88 Homolog (Chlamydomonas); Intraflagellar Transport 88 Homolog; Testicular Tissue Protein Li 93; HTG737; Tg737; DAF19
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human IFT88 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6G4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
  • 基因功能參考文獻：
    1. BFGF also upregulated the mRNA and protein expression of IFT88 in primary cultured chondrocytes. PMID: 28901443
    2. Data suggest that the function of the fusion transcript crystallin, lambda 1 protein - intraflagellar transport 88 (CRYL1-IFT88) is closed to CRYL1 because it contained most of domain of CRYL1. PMID: 28489570
    3. multivariate Cox regression analyses demonstrated that Tg737 expression was an independent factor for predicting the overall survival of hepatocellular carcinoma patients PMID: 28663060
    4. MiR-548a-5p negatively regulates the tumor inhibitor gene Tg737 and promotes tumorigenesis in vitro and in vivo, indicating its potential as a novel therapeutic target for hepatocellular carcinoma. PMID: 27340352
    5. subtle regulation of IFT and associated cilia structure, tunes the wnt response controlling stem cell differentiation. PMID: 24346024
    6. this work suggests that Tg737 is involved in the invasion and migration of hepatoma cells under hypoxia, with the involvement of the polycystin-1, IL-8, and TGF-beta1 signaling pathway PMID: 22974282
    7. A mutation in IFT88 causes a hitherto unknown human ciliopathy. PMID: 22941275
    8. Data show that IFT88 depletion induces mitotic defects in human cultured cells, in kidney cells from the IFT88 mouse mutant Tg737(orpk) and in zebrafish embryos. PMID: 21441926
    9. The results indicate that loss of heterozygosity of the tumor suppressor gene Tg737 may play an important role in the carcinogenetic mechanism of liver cancer stem cells. PMID: 20300861
    10. IFT88 is a centrosomal protein regulating G1-S transition in non-ciliated cells. PMID: 17264151

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium, flagellum.
  • 組織特異性：
    Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20606

    OMIM: 600595

    KEGG: hsa:8100

    STRING: 9606.ENSP00000323580

    UniGene: Hs.187376