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  4. HNRNPUL1 Recombinant Monoclonal Antibody

HNRNPUL1 Recombinant Monoclonal Antibody

  • 中文名稱：
    HNRNPUL1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA289636A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of HNRNPUL1 expression in HAP-1 cells using HNRNPUL1 antibody. Green, isotype control; red, HNRNPUL1.
    • Immunocytochemical staining of HAP-1 cells with HNRNPUL1 antibody. Nuclei were stained blue with DAPI; HNRNPUL1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Immunohistochemistry was performed on paraffin-embedded human breast carcinoma using HNRNPUL1 antibody. Antigen retrieval was done in sodium citrate buffer (pH 6.0). DAB was used for detection, with hematoxylin counterstaining. Images were acquired using a Nikon Ci-L Plus microscope (40× objective). Scale bar: 25 μm.
    • Western blotting analysis using HNRNPUL1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with HNRNPUL1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    HNRNPUL1
  • 別名：
    HNRNPUL1; Heterogeneous Nuclear Ribonucleoprotein U Like 1; E1B-AP5; E1BAP5; HNRPUL1; Heterogeneous Nuclear Ribonucleoprotein U-Like Protein 1; Adenovirus Early Region 1B-Associated Protein 5; E1B-55 KDa-Associated Protein 5; E1B 55kDa Associated Protein 5; FLJ12944
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human HNRNPUL1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    23D10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
    IHC 1:100-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.
  • 基因功能參考文獻(xiàn)：
    1. we define the arginines within the RGG/RG motifs as the site of methylation by PRMT1 both in vitro and in vivo. The arginines within the human hnRNPUL1 RGG/RG motifs were substituted with lysines to generate hnRNPUL1(RK). PMID: 26020839
    2. U7 snRNP represses histone gene transcription under cell cycle-arrested conditions. hnRNP UL1 is responsible for U7 snRNP-dependent transcriptional repression of replication-dependent histone genes. PMID: 22451911
    3. Despite the limitations, hnRPUL1 and PARP1 were downregulated in renal cell carcinoma and connected with the prognosis. PMID: 24595077
    4. hnRPUL1 as a new component related to PARP1 in DNA damage response and repair PMID: 23577092
    5. hnRNPUL1 and -2 function downstream of MRN and CtBP-interacting protein (CtIP) to promote recruitment of the BLM helicase to DNA breaks. PMID: 22365830
    6. E1B-AP5 is a novel surface molecule that is involved in the undifferentiated state of human embryonic stem cells PMID: 21083500
    7. Regulation of transcripton by this protein is mediated by complex formation with BRD7 PMID: 12489984
    8. Variants in 2 genes were associated with early-onset myocardial infarct: VAMP8, which is involved in platelet degranulation, and HNRPUL1, which encodes a ribonuclear protein. PMID: 16690874
    9. Taken together, these results define a role for E1B-AP5 in ATR signaling pathways activated during adenovirus infection. PMID: 18480432
    10. Human E1B-AP5 binds to adenovirus E1B-55kDa protein. PMID: 9733834

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  • 亞細(xì)胞定位：
    Nucleus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17011

    OMIM: 605800

    KEGG: hsa:11100

    STRING: 9606.ENSP00000375863

    UniGene: Hs.155218