H1-0 Recombinant Monoclonal Antibody
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中文名稱：H1-0 Recombinant Monoclonal Antibody
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貨號：CSB-RA598755A0HU
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規(guī)格：￥1320
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圖片：
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Immunocytochemical staining of C2C12 cells with Histone H1.0 antibody. Nuclei were stained blue with DAPI; Histone H1.0 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm. -
Western blotting analysis using histone H1.0 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with histone H1.0 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：H1-0
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別名：H1-0; H1.0 Linker Histone; H1.0; H1F0; H1FV; H1 Histone Family Member 0; H1.0, H1(0), H1-0; Histone H1(0); Histone H1.0; Histone H1'; H1 Histone Family, Member 0; H10
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反應(yīng)種屬：Human, Mouse, Rat
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免疫原：Recombinant Human H1-0 protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：12E1
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, ICC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 ICC 1:100-1:1000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
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基因功能參考文獻(xiàn)：
- H1.X moves more rapidly than other linker histones in vivo Domain swapping between H1.0 and H1.X suggests that the globular domain (GD) and C-terminal domain (CTD) of H1.X independently contribute to the dynamic behavior of H1.X. PMID: 27528617
- this study shows that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth. PMID: 27708074
- The N-terminal domain contributes toward the differential chromatin binding affinity, whereas the C-terminal domain contributes toward distinct nucleosomal interface of isotypes H10 and H1c. PMID: 22334665
- nuclear transport of H1 histones requires a heterodimeric nuclear import receptor PMID: 12080050
- H1(0)histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1(0) expression. PMID: 12149419
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亞細(xì)胞定位：Nucleus. Chromosome. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
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蛋白家族：Histone H1/H5 family
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數(shù)據(jù)庫鏈接：
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