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GSC Recombinant Monoclonal Antibody

  • 中文名稱：
    GSC Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA153275A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Immunocytochemical staining of HepG2 cells with Goosecoid homeobox antibody. Nuclei were stained blue with DAPI; Goosecoid homeobox was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using goosecoid homeobox antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with goosecoid homeobox antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    GSC
  • 別名：
    GSC; Goosecoid Homeobox; Homeobox Protein Goosecoid; GSC1; SAMS
  • 反應(yīng)種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human GSC protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    2E3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    ICC 1:100-1:1000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals.
  • 基因功能參考文獻(xiàn)：
    1. Performed mutational analysis of TCOF1, GSC, and HOXA2 to determine the mutational features of the 3 genes in Chinese patients with Treacher Collins syndrome. PMID: 27526242
    2. We find that DIGIT is divergent to Goosecoid (GSC) and expressed during endoderm differentiation. Deletion of the SMAD3-occupied enhancer proximal to DIGIT inhibits DIGIT and GSC expression and definitive endoderm differentiation. PMID: 27705785
    3. 5 genomic variants in GSC, HOXA2 and PRKRA were identified through mutational analysis in Chinese patients with microtia. PMID: 28109504
    4. GSC is also a prognostic factor for poor survival and metastasis of HCC, which suggests its potential as a therapeutic target for metastatic HCC. PMID: 25343336
    5. Results suggest that GSC is the most potential biomarker of drug response and poor prognosis in ovarian serous carcinomas. PMID: 24858567
    6. EtOH exposure increased the expression of an organizer specific gene, goosecoid, in human embryonic carcinoma cells. PMID: 23378141
    7. SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid. PMID: 24290375
    8. GSC represses EVX1 expression and is required for development of anterior primitive-streak-like cell progeny in response to activin. PMID: 22178155
    9. The goosecoid gene mutation in exon 3 may be involved in the malformation events (microtia) in this family. PMID: 20195123
    10. Goosecoid promotes tumor cell malignancy and suggest that other conserved organizer genes may function similarly in human cancer PMID: 17142318
    11. GSC protein might contribute to the observed phenotype. PMID: 18074379

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  • 相關(guān)疾病：
    Short stature, auditory canal atresia, mandibular hypoplasia, skeletal abnormalities (SAMS)
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family, Bicoid subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4612

    OMIM: 138890

    KEGG: hsa:145258

    STRING: 9606.ENSP00000238558

    UniGene: Hs.440438