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  4. EOGT Recombinant Monoclonal Antibody

EOGT Recombinant Monoclonal Antibody

  • 中文名稱：
    EOGT Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA783392A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of EOGT expression in HT-1080 cells using EOGT antibody. Green, isotype control; red, EOGT.
    • Immunocytochemical staining of HT-1080 cells with EOGT antibody. Nuclei were stained blue with DAPI; EOGT was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using EOGT antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with EOGT antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    EOGT
  • 別名：
    EOGT; EGF Domain Specific O-Linked N-Acetylglucosamine Transferase; AER61; EGF Domain-Specific O-Linked N-Acetylglucosamine (GlcNAc) Transferase; EGF Domain-Specific O-Linked N-Acetylglucosamine Transferase; Extracellular O-Linked N-Acetylglucosamine Transferase; AER61 Glycosyltransferase; FLJ33770; C3orf64; EOGT1; Chromosome 3 Open Reading Frame 64; EGF-O-GlcNAc Transferase; EC 2.4.1.255; C3ORF64; AOS4
  • 反應(yīng)種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human EOGT protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    1F10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.
  • 基因功能參考文獻(xiàn)：
    1. Analysis of midluteal endometrial biopsies revealed an inverse correlation between endometrial EOGT and ENHO expression and body mass index. obesity impairs the EOGT-adropin axis in decidual cells, which in turn points toward a mechanistic link between metabolic disorders and adverse pregnancy outcome. PMID: 29244071
    2. Eogt resulted in defective retinal angiogenesis, with a mild phenotype similar to that caused by reduced Notch signaling in retina. Combined deficiency of different Notch1 mutant alleles exacerbated the abnormalities in Eogt(-/-) retina, and Notch target gene expression was decreased in Eogt(-/-)endothelial cells. PMID: 28395734
    3. Studies provide evidence that mutations in EOGT lead to autosomal recessive Adams-Oliver Syndrome. [review] PMID: 28408480
    4. c.1074delA mutation segregates with Adams-Oliver syndrome in the Bedouin family. PMID: 23860037
    5. Mutations in EOGT confirm the genetic heterogeneity of autosomal-recessive Adams-Oliver syndrome. PMID: 23522784

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  • 相關(guān)疾病：
    Adams-Oliver syndrome 4 (AOS4)
  • 亞細(xì)胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Glycosyltransferase 61 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28526

    OMIM: 614789

    KEGG: hsa:285203

    STRING: 9606.ENSP00000295571

    UniGene: Hs.518059