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  4. ELP4 Recombinant Monoclonal Antibody

ELP4 Recombinant Monoclonal Antibody

  • 中文名稱：
    ELP4 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA907689A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of ELP4 expression in C2C12 cells using ELP4 antibody. Green, isotype control; red, ELP4.
    • Immunocytochemical staining of C2C12 cells with ELP4 antibody. Nuclei were stained blue with DAPI; ELP4 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
    • Western blotting analysis using ELP4 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ELP4 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ELP4
  • 別名：
    ELP4; Elongator Acetyltransferase Complex Subunit 4; PAXNEB; Elongator Complex Protein 4; PAX6 Neighbor Gene Protein; C11orf19; HELP4; Elongation Protein 4 Homolog (S. Cerevisiae); Chromosome 11 Open Reading Frame 19; Elongation Protein 4 Homolog; DJ68P15A.1; C11ORF19; PAX6NEB; AN2; AN
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human ELP4 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    15D7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
  • 基因功能參考文獻：
    1. Our results suggest that ELP4 deletions are highly likely to be pathogenic, predisposing to a range of neurodevelopmental phenotypes from ASD to language impairment and epilepsy. PMID: 26010655
    2. Results show no difference in BDNF and ELP4 genotype frequencies between benign epilepsy with centrotemporal spikes patients and controls; haplotype analysis also revealed no statistical difference PMID: 25301525
    3. No association of SNPs in the ELP4 gene was detected in rolandic epilepsy patients. PMID: 24995671
    4. Data suggest that a non-coding mutation in ELP4 impairs brain-specific Elongator-mediated interaction of genes implicated in brain development, resulting in susceptibility to seizures and neurodevelopmental disorders. PMID: 19172991
  • 相關疾病：
    Aniridia 2 (AN2)
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    ELP4 family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 1171

    OMIM: 606985

    KEGG: hsa:26610

    STRING: 9606.ENSP00000298937

    UniGene: Hs.175534