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  4. DSC3 Recombinant Monoclonal Antibody

DSC3 Recombinant Monoclonal Antibody

  • 中文名稱：
    DSC3 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA830069A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Desmocollin 3 expression in HeLa cells using Desmocollin 3 antibody. Green, isotype control; red, Desmocollin 3.
    • Immunocytochemical staining of Hela cells with Desmocollin 3 antibody. Nuclei were stained blue with DAPI; Desmocollin 3 with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
    • Immunohistochemistry was performed on paraffin-embedded human skin tissue using desmocollin 3 antibody. Antigen retrieval was done in sodium citrate buffer (pH 6.0). DAB was used for detection, with hematoxylin counterstaining. Images were acquired using a Nikon Ci-L Plus microscope (40× objective). Scale bar: 25 μm.
    • Immunohistochemistry was performed on paraffin-embedded human esophageal carcinoma using desmocollin 3 antibody. Antigen retrieval was done in sodium citrate buffer (pH 6.0). DAB was used for detection, with hematoxylin counterstaining. Images were acquired using a Nikon Ci-L Plus microscope (40× objective). Scale bar: 25 μm.
    • Western blotting analysis using Desmocollin 3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Desmocollin 3 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    DSC3
  • 別名：
    DSC3; Desmocollin 3; CDHF3; DSC1; DSC2; DSC4; DSC; Cadherin Family Member 3; Desmocollin-3; Desmocollin-4; HT-CP
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human DSC3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    18B5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
    IHC 1:100-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
  • 基因功能參考文獻：
    1. The Findings of this study imply early alteration of the substantia nigra in XDP mutation carriers prone to develop parkinsonism. PMID: 28094105
    2. Data show that fetal pMSCs (mesenchymal stromal cells) expressing the highest levels of desmoglein 2, desmocollin 3 and plakophilin 2, followed by maternal pMSCs, while bmMSCs expressed the lowest levels. PMID: 28154962
    3. Napsin-A, and Desmocollin-3 were sensitive and specific markers for the diagnosis of AC and SCC, respectively. Both markers allowed classification of 54/60 cases into either AC or SCC. PMID: 26710975
    4. Suggest that Dsc3 can mediate FSH-induced ovarian cancer cell proliferation by activating the EGFR/Akt signaling pathway. PMID: 26261554
    5. data suggests that DNA methylation contributes to down-regulation of DSC3 in prostate cancer, and loss of DSC3 predicts poor clinical outcome. PMID: 24664224
    6. The data show an important role of physiologically occurring transcript d2-d4 in normal brain function. Interference with this role by DSC3 is a likely pathological mechanism in X-chromosomal dystonia parkinsonism syndrome PMID: 23184149
    7. The p53 target gene desmocollin 3 acts as a novel tumor suppressor through inhibiting EGFR/ERK pathway in human lung cancer. PMID: 22941060
    8. These findings demonstrate that IgG autoantibodies against an additional component of the desmosomes, Dsc3, induce loss of keratinocyte adhesion and thus may contribute to blister formation in pemphigus. PMID: 21281804
    9. Methylation status of DSC3 DNA is a prognostic marker for colorectal cancer. P53 appears to have an important role in regulating DSC3 expression. PMID: 21364582
    10. Autoimmunity to DSC3 in Pemphigus vulgaris. PMID: 20952584
    11. Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both MASPIN and desmocollin 3 (DSC3) to be p53-target genes, even though both genes are silenced in association with aberrant cytosine methylation of their promoters PMID: 12789271
    12. Lss of DSC3 expression is a common event in primary breast tumor specimens, and DSC3 gene silencing in breast tumors is frequently linked to aberrant cytosine methylation and concomitant changes in chromatin structure. PMID: 16168112
    13. Increased Dsc3 protein is associated with colorectal cancer PMID: 17088906
    14. results suggest an abnormal expression of Dsc3, Dsg3, & beta-catenin induced in the progression of oral carcinomas & that Dsc3 expression level might be related to the regulation of beta-catenin in lymph node metastasis and cell proliferation in OSCCs. PMID: 17846785
    15. Desmocollin-3 was expressed in almost half of the undifferentiated large-cell cancers PMID: 19287461
    16. Both the binding of desmocollin 3 (Dsc3) to plakoglobin and Dsc3 phosphorylation are involved in Dsc3 binding to desmoglein 3 (Dsg3) during Ca2+ -induced desmosome assembly. PMID: 19348003
    17. loss of heterophilic Dsc3/Dsg1 binding may contribute to pemphigus skin blistering PMID: 19717567
    18. a human desmocollin-3 (DSC3) nonsense mutation underlies hereditary hypotrichosis and recurrent skin vesicles PMID: 19765682

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  • 相關疾病：
    Hypotrichosis and recurrent skin vesicles (HRSV)
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
  • 組織特異性：
    Epidermis, buccal mucosa, esophagus and cervix.
  • 數據庫鏈接：

    HGNC: 3037

    OMIM: 600271

    KEGG: hsa:1825

    STRING: 9606.ENSP00000353608

    UniGene: Hs.41690