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DPP3 Recombinant Monoclonal Antibody

  • 中文名稱：
    DPP3 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA091549A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of dipeptidyl peptidase 3 expression in H9C2 cells using dipeptidyl peptidase 3 antibody. Green, isotype control; red, dipeptidyl peptidase 3.
    • Western blotting analysis using dipeptidyl peptidase 3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with dipeptidyl peptidase 3 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    DPP3; Dipeptidyl Peptidase 3; Enkephalinase B; Dipeptidyl Aminopeptidase III; Dipeptidyl Arylamidase III; Dipeptidyl Peptidase III; EC 3.4.14.4; DPP III; Dipeptidylpeptidase III; Dipeptidyl-Peptidase 3; Dipeptidylpeptidase 3; DPPIII
  • 反應種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human DPP3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    20F1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro).
  • 基因功能參考文獻：
    1. We conclude that DPP 3 may influence the cellular expression of Ang-(1-7) and potentially reflect a therapeutic target to augment the actions of the peptide PMID: 27315786
    2. biological function of human dipeptidyl peptidase III PMID: 26887037
    3. several crystal structures of complexes of human dipeptidyl peptidase III with different peptides. PMID: 27025154
    4. Evidence for concurrent expression of hDPP III mRNA V-I and V-II in multiple human tumor derived cell lines. PMID: 27153830
    5. the DPP III conformational landscape and the influence of ligand binding on the protein structure and dynamics, was investigated. PMID: 26334575
    6. Kinetic studies revealed that the single mutant D496G lost selectivity due to the increase of the Km value. The D496G, but not S504G, showed significantly decreased binding of peptides with N-terminal arginine, and of tynorphin. PMID: 25581752
    7. The study used three different conformations of human dipeptidyl-peptidase III (DPP III) to investigate the influence of the protein environment on ligand binding and the Zn(2+) coordination. PMID: 25192149
    8. Deletion/mutagenesis of C/EBP-beta binding motif of DPP III promoter significantly increased its activity and abolished its responsiveness to IL-6 in glioblastoma cells. PMID: 24472318
    9. The activity of the yeast and human dipeptidyl peptidase III were examined. PMID: 23362197
    10. Combined results of mutational analysis and mass spectrometry suggest that glutathionylation (formation of mixed disulfide) of Cys176 and Cys654 contributes to human DPP III inactivation by oxidized glutathione. PMID: 23667907
    11. Amplification and mRNA overexpression of the DPP3 gene is associated with squamous cell lung carcinomas. PMID: 23382044
    12. results provide the basis for the design of specific inhibitors that enable the elucidation of the exact role of DPP III and the exploration of its potential as a target of pain intervention strategies PMID: 22493238
    13. Ets-1/Elk-1 is a critical mediator of DPP3 transcription in human glioblastoma cells. PMID: 20236318
    14. In malignant neoplasms of the ovary DPP III activity increased with growing histologic grade. PMID: 14529681
    15. the conserved tyrosine could be involved in transition state stabilization during the catalytic action of M49 peptidases. PMID: 18163885

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  • 亞細胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Peptidase M49 family
  • 組織特異性：
    Detected in placenta (at protein level). Detected in erythrocytes (at protein level).
  • 數據庫鏈接：

    HGNC: 3008

    OMIM: 606818

    KEGG: hsa:10072

    STRING: 9606.ENSP00000353701

    UniGene: Hs.502914