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  4. CSDE1 Recombinant Monoclonal Antibody

CSDE1 Recombinant Monoclonal Antibody

  • 中文名稱：
    CSDE1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA960273A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Immunofluorescence staining of MCF-7 cell with CSB-RA960273A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Overlay Peak curve showing MCF-7 cells stained with CSB-RA960273A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR), CSDE1, D1S155E KIAA0885 NRU UNR
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide from human CSDE1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    11B11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules.; (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA.
  • 基因功能參考文獻：
    1. CSDE1 post-transcriptionally modulates core components of multiple regulatory nodes of human embryonic stem cell identity, neuroectoderm commitment and neurogenesis and acts as a negative regulator of neural differentiation and neurogenesis. PMID: 29129916
    2. UNR/CDSE1 expression is correlated with outcome in patients with resectable pancreatic ductal adenocarcinoma PMID: 28763470
    3. Results identify UNR as an oncogenic modulator of melanoma progression, unraveling the underlying molecular mechanisms. UNR seems to regulate translation elongation of Vimentin and RAC1 mRNAs. PMID: 27908735
    4. Studies indicate that Unr (upstream of N-ras) is post-translationally modified by phosphorylation and lysine acetylation. PMID: 26614667
    5. Hepsin suppressed CDK11p58 internal ribosome entry site activity in prostate cancer cells by modulating UNR expression and eIF-2alpha phosphorylation. PMID: 25576733
    6. Study suggests TRIM33 and NRAS-CSDE1 as candidate genes for autism, and may provide a novel insight into the etiology of autism PMID: 24189344
    7. unr and nPTB act as RNA chaperones by changing the structure of the IRES into one that permits translation initiation PMID: 12667457
    8. UNR translation is regulated by an internal ribosome entry site that is downregulated by polypyrimidine tract binding protein. PMID: 15928332
    9. regulation of IRES-mediated translation by hnRNP C1/C2 and Unr might be important in mitosis PMID: 17159903
    10. The data suggest that Unr acts as an RNA chaperone on rhinovirus RNA 5' UTR to maintain a complex tertiary internal ribosome entry site structure required for translational competency. PMID: 17947529

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, P-body.
  • 數據庫鏈接：

    HGNC: 29905

    OMIM: 191510

    KEGG: hsa:7812

    STRING: 9606.ENSP00000407724

    UniGene: Hs.69855