国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. COPS8 Recombinant Monoclonal Antibody

COPS8 Recombinant Monoclonal Antibody

  • 中文名稱：
    COPS8 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA172524A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of COPS8 expression in HepG2 cells using COPS8 antibody. Green, isotype control; red, COPS8.
    • Immunocytochemical staining of HepG2 cells with COPS8 antibody. Nuclei were stained blue with DAPI; COPS8 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm.
    • Western blotting analysis using COPS8 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with COPS8 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    COPS8
  • 別名：
    COPS8; COP9 Signalosome Subunit 8; CSN8; SGN8; COP9; JAB1-Containing Signalosome Subunit 8; COP9 Signalosome Complex Subunit 8; Signalosome Subunit 8; COP9 Homolog; MGC1297; COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis); COP9 Constitutive Photomorphogenic Homolog Subunit 8; HCOP9
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human COPS8 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6D7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 基因功能參考文獻：
    1. Among 479 individuals affected with clear cell renal cell carcinoma, only synonymous variants were found in COPS8 and one of the missense variants in ACKR3:c.892C>T, was observed in 4/479 individuals screened PMID: 28063109
    2. Data indicate that silencing of Csn8 caused an increased growth rate, whereas silencing of Csn5 impaired proliferation in HeLa cells. PMID: 23689509
    3. miR-146a expression is up-regulated in a majority of gastric cancers where it targets CARD10 and COPS8, inhibiting GPCR-mediated activation of NF-kappaB. PMID: 22992343
    4. proteomic-based approach can broaden our understanding of the functions of the CSN in contexts such as viral-host interactions or immune activation in their natural milieu PMID: 22414063
    5. analysis of the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3 PMID: 20399188
    6. DDB2 and CSA are each integrated into nearly identical complexes via interaction with DDB1. Both complexes contain cullin 4A and Roc1 and display ubiquitin ligase activity. They also contain the COP9 signalosome (CSN) PMID: 12732143
    7. The COP9 signalosome (CSN) controls NF-kappaB by deubiquitinylation of IkappaBalpha. PMID: 17318178
    8. COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination PMID: 18424433

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN8 family
  • 數據庫鏈接：

    HGNC: 24335

    OMIM: 616011

    KEGG: hsa:10920

    STRING: 9606.ENSP00000346340

    UniGene: Hs.531713