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  4. CLSTN1 Recombinant Monoclonal Antibody

CLSTN1 Recombinant Monoclonal Antibody

  • 中文名稱：
    CLSTN1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA069777A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of calsyntenin 1 expression in HT-1080 cells using calsyntenin 1 antibody. Green, isotype control; red, calsyntenin 1.
    • Immunocytochemical staining of HT-1080 cells with Calsyntenin 1 antibody. Nuclei were stained blue with DAPI; Calsyntenin 1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using calsyntenin 1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with calsyntenin 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CLSTN1
  • 別名：
    CLSTN1; Calsyntenin 1; KIAA0911; CDHR12; CSTN1; Alzheimer-Related Cadherin-Like Protein; Cadherin-Related Family Member 12; Non-Classical Cadherin XB31alpha; Alcadein-Alpha; Calsyntenin-1; ALC-ALPHA; XB31alpha; Alcalpha1; Alcalpha2; Alc-Alpha; PIK3CD; CST-1; CS1
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human CLSTN1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    2D1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals.
  • 基因功能參考文獻：
    1. Results suggests that APP partially compensates for defective Alcalpha in anterograde transport by providing an alternative cargo receptor for kinesin-1. PMID: 29093024
    2. Calsyntenin-1 contributes to the early stages of the hepatitis C virus replication cycle and the formation of the replication complex. PMID: 27221318
    3. Increased plasma p3-Alcalpha35, a major fragment of alcalpha1, may indicate an endophenotype in Alzheimer's disease patients with progressive cognitive impairment. PMID: 24305499
    4. Increased plasma p3-alcadein (alc) alpha, evident in the early stages of cognitive impairment, suggests that alc metabolites are useful plasma biomarkers of Alzheimer's disease. PMID: 22571980
    5. findings show that calsyntenin-1 is reduced in Alzheimer's disease brains and that the extent of this reduction correlates with increased amyloid-beta PMID: 22434822
    6. CLSTN1 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    7. Phosphorylation of KLC1 at serine 460 modulates binding and trafficking of calsyntenin-1. PMID: 21385839
    8. Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation [alcalpha1, alcbeta, alcgamma] PMID: 15037614

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  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane. Cell projection, neuron projection. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein. Nucleus.
  • 組織特異性：
    Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level).
  • 數據庫鏈接：

    HGNC: 17447

    OMIM: 611321

    KEGG: hsa:22883

    STRING: 9606.ENSP00000366513

    UniGene: Hs.29665