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  4. CARS1 Recombinant Monoclonal Antibody

CARS1 Recombinant Monoclonal Antibody

  • 中文名稱：
    CARS1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA276782A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Cysteinyl-tRNA synthetase 1 expression in HT-1080 cells using Cysteinyl-tRNA synthetase 1 antibody. Green, isotype control; red, Cysteinyl-tRNA synthetase 1.
    • Immunocytochemical staining of HT-1080 cells with Cysteinyl-tRNA synthetase 1 antibody. Nuclei were stained blue with DAPI; Cysteinyl-tRNA synthetase 1 was stained magenta with Alexa Fluor? 647. Images were taken using leica stellaris 5. Protein abundance based on laser intensity and smart gain: Medium. Scale bar: 20 μm.
    • Western blotting analysis using Cysteinyl-tRNA synthetase 1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Cysteinyl-tRNA synthetase 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CARS1
  • 別名：
    CARS1; Cysteinyl-TRNA Synthetase 1; CARS; Cysteine TRNA Ligase1,Cytoplasmic; Cysteine--TRNA Ligase, Cytoplasmic; Cysteinyl-TRNA Synthetase; EC 6.1.1.16; Cysteine Translase; MGC:11246; EC 6.1.1; MCDDBH; CYSRS; CysRS; MDBH
  • 反應種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human CARS1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    19H8
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).
  • 基因功能參考文獻：
    1. Four single nucleotide polymorphisms (SNPs) of CARS were significantly associated with gastric cancer risk in both the discovery stage and the validation stage PMID: 28409418
    2. The risk (G and C) and non-risk (C and T) allele frequencies of the SNPs at the rs1888747 and rs739401 loci of FRMD3 and CARS, respectively, did not differ significantly between the diabetics with (case) and without (control) nephropathy (P > 0.05). PMID: 26909942
    3. Loss of CARS, the cysteinyl-tRNA synthetase, suppresses ferroptosis induced by erastin, which inhibits the cystine-glutamate antiporter known as system xc(-). PMID: 26184909
    4. CARS is a novel fusion partner of anaplastic lymphoma kinase in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor cases. PMID: 12112524
    5. Specificity of anticodon recognition by human CysRS is higher than that of its bacterial counterparts. PMID: 17303165

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  • 相關疾病：
    A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with ALK.
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Class-I aminoacyl-tRNA synthetase family
  • 數據庫鏈接：

    HGNC: 1493

    OMIM: 123859

    KEGG: hsa:833

    STRING: 9606.ENSP00000369897

    UniGene: Hs.274873



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