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AVEN Recombinant Monoclonal Antibody

  • 中文名稱：
    AVEN Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA109552A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Apoptosis and caspase activation inhibitor expression in HepG2 cells using Apoptosis and caspase activation inhibitor antibody. Green, isotype control; red, Apoptosis and caspase activation inhibitor.
    • Immunocytochemical staining of HepG2 cells with Apoptosis and caspase activation inhibitor antibody. Nuclei were stained blue with DAPI; Apoptosis and caspase activation inhibitor was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using apoptosis and caspase activation inhibitor antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with apoptosis and caspase activation inhibitor antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    AVEN
  • 別名：
    AVEN; Apoptosis And Caspase Activation Inhibitor; Cell Death Regulator Aven; PDCD12; Programmed Cell Death 12; Apoptosis, Caspase Activation Inhibitor
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human AVEN protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6G6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Protects against apoptosis mediated by Apaf-1.
  • 基因功能參考文獻：
    1. AVEN and BIRC6 are inhibited by combination therapy of miR-30e and proanthocyanidin in glioblastoma stem cells PMID: 27388765
    2. The Aven RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes. PMID: 26267306
    3. the expression of Aven is regulated by the Akt signaling pathway through cathepsin D activity, which contributes to the sensitivity of cancer cells to chemotherapeutic agents. PMID: 25573060
    4. The findings implicate Aven in ATR-Chk1 signalling and point towards Chk1 inhibition as a strategy to sensitize human osteosarcomas to chemotherapy. PMID: 25757065
    5. Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms. PMID: 22751129
    6. a model of Aven activation by which its N-terminal inhibitory domain is removed by CathD-mediated proteolysis, thereby unleashing its cytoprotective function. PMID: 22388353
    7. The results suggest that deregulation of the expression of the apoptosis inhibitor Aven may be related to male factor infertility. PMID: 21718987
    8. the expression level of aven mRNA in de novo AML patients obviously increases PMID: 20030919
    9. Results suggest that the regulation of Exportin-1/CRM1-dependent nucleocytoplasmatic traffic of Aven could modulate its ability to influence cell cycle progression. PMID: 20935510
    10. Aven expression was found to be higher in patients >or=10 years old or <1 year, and with unfavorable cytogenetic abnormalities. It was also significantly higher in relapsed patients in the standard-risk group and an independent poor prognostic factor. PMID: 16388850
    11. point mutation observed by transcriptome sequencing of malignant pleural mesothelioma tumors PMID: 18303113
    12. These results identify Aven as a new ATM activator and describe a positive feedback loop operating between Aven and ATM; in aggregate, these findings place Aven, a known apoptotic inhibitor, as a critical transducer of the DNA-damage signal. PMID: 18571408

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  • 亞細胞定位：
    Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular membranes.
  • 組織特異性：
    Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 13509

    OMIM: 605265

    KEGG: hsa:57099

    STRING: 9606.ENSP00000306822

    UniGene: Hs.555966