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  4. ATG4C Recombinant Monoclonal Antibody

ATG4C Recombinant Monoclonal Antibody

  • 中文名稱：
    ATG4C Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA953219A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Atg4C expression in HepG2 cells using Atg4C antibody. Green, isotype control; red, Atg4C.
    • Immunocytochemical staining of HepG2 cells with Atg4C antibody. Nuclei were stained blue with DAPI; Atg4C was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using ATG4C antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ATG4C antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ATG4C; Autophagy Related 4C Cysteine Peptidase; AUTL3; APG4C; AUTL1; Autophagy-Related Cysteine Endopeptidase 3; Autophagy-Related Protein 4 Homolog C; AUT-Like 3 Cysteine Endopeptidase; Cysteine Protease ATG4C; Autophagin-3; FLJ14867; HsAPG4C; AUT (S. Cerevisiae)-Like 1, Cysteine Endopeptidase; AUT-Like 1, Cysteine Endopeptidase (S. Cerevisiae); ATG4 Autophagy Related 4 Homolog C (S. Cerevisiae); APG4 Autophagy 4 Homolog C (S. Cerevisiae); Epididymis Secretory Sperm Binding Protein; Autophagy Related 4C, Cysteine Peptidase; ATG4 Autophagy Related 4 Homolog C; AUT-Like 1, Cysteine Endopeptidase; APG4 Autophagy 4 Homolog C; EC 3.4.22.-; EC 3.4.22; APG4-C
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ATG4C protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    5G9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:2000-1:10000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
  • 基因功能參考文獻：
    1. association between SNPs and Kashin-Beck disease PMID: 27742532
    2. We demonstrate that, in breast cancer cells, ATM and ATG4C are essential drivers of mammosphere formation, suggesting that their targeting may improve current approaches to eradicate breast cancer cells with a stem-like phenotype. PMID: 28423511
    3. miR-376b controls autophagy by directly regulating intracellular levels of two key autophagy proteins, ATG4C and BECN1. PMID: 22248718
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C54 family
  • 數據庫鏈接：

    HGNC: 16040

    OMIM: 611339

    KEGG: hsa:84938

    STRING: 9606.ENSP00000322159

    UniGene: Hs.7353



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