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  4. ARHGAP5 Recombinant Monoclonal Antibody

ARHGAP5 Recombinant Monoclonal Antibody

  • 中文名稱：
    ARHGAP5 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA908606A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Rho GTPase activating protein 5 expression in C2C12 cells using Rho GTPase activating protein 5 antibody. Green, isotype control; red, Rho GTPase activating protein 5.
    • Immunocytochemical staining of C2C12 cells with Rho GTPase activating protein 5 antibody. Nuclei were stained blue with DAPI; Rho GTPase activating protein 5 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using Rho GTPase activating protein 5 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Rho GTPase activating protein 5 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ARHGAP5; Rho GTPase Activating Protein 5; P190-B; Rho-Type GTPase-Activating Protein 5; Rho GTPase-Activating Protein 5; Growth Factor Independent 2; P190BRhoGAP; RhoGAP5; RHOGAP5; GFI2; P100 RasGAP-Associated P105 Protein; P105 RhoGAP; P190BRHOGAP
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human ARHGAP5 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    17A5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    GTPase-activating protein for Rho family members.
  • 基因功能參考文獻：
    1. only collagen-IV elicits the formation of proteolytically active podosomes through a mechanism involving increased Src phosphorylation, p190RhoGAP-B (also known as ARHGAP5) relocalisation and MT1-MMP (also known as MMP14) cell surface exposure at podosome sites. PMID: 27231093
    2. Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) in the Asian comparison. PMID: 28100790
    3. This newly identified miR-744/ARHGAP5 pathway provides further insight into the progression and metastasis of NPC and indicates potential novel therapeutic targets for NPC. PMID: 25961434
    4. Ectopic expression of p190B suppressed the miR-494-induced EGFR upregulation. PMID: 24316134
    5. The expression level of miR-486-5p was inversely correlated with that of ARHGAP5. PMID: 23474761
    6. RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis. PMID: 23552690
    7. Data indicate a role for p120-catenin (amino acids 820-843) domain in the p120-catenin.p190RhoGAP signaling complex assembly and membrane targeting. PMID: 23653363
    8. A cell cycle-regulated reduction in endogenous p190 levels is linked to completion of cytokinesis and generation of viable cell progeny. PMID: 14610059
    9. precise control of p190-B Rho GTPase-activating protein activity is critical for normal branching morphogenesis during mammary gland development PMID: 16469769
    10. Results link Cdk5 to Rho-ROCK signaling via Src and p190RhoGAP and implicate Cdk5 in the regulation of cell contraction, attachment, and migration. PMID: 19822667

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  • 亞細胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 組織特異性：
    Detected in skin fibroblasts (at protein level).
  • 數據庫鏈接：

    HGNC: 675

    OMIM: 602680

    KEGG: hsa:394

    STRING: 9606.ENSP00000371897

    UniGene: Hs.592313