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  4. ALKBH4 Recombinant Monoclonal Antibody

ALKBH4 Recombinant Monoclonal Antibody

  • 中文名稱：
    ALKBH4 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA547941A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of ALKBH4 expression in HeLa cells using ALKBH4 antibody. Green, isotype control; red, ALKBH4.
    • Immunocytochemical staining of Hela cells with ALKBH4 protein antibody. Nuclei were stained blue with DAPI; ALKBH4 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using ALKBH4 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ALKBH4 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ALKBH4
  • 別名：
    ALKBH4; AlkB Homolog 4, Lysine Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 4; Alkylated DNA Repair Protein AlkB Homolog 4; DNA N6-Methyl Adenine Demethylase ALKBH4; Lysine-Specific Demethylase ALKBH4; FLJ20013; ABH4; Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH4; AlkB, Alkylation Repair Homolog 4 (E. Coli); AlkB Homolog 4, Lysine Demthylase; AlkB, Alkylation Repair Homolog 4; EC 1.14.11.51; EC 1.14.11.-
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ALKBH4 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    2C12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.
  • 基因功能參考文獻：
    1. ALKBH4-dependent actin demethylation regulates actomyosin function by promoting actin-non-muscle myosin II interaction. PMID: 23673617
    2. The regions mediating binding to ALKBH4 comprised domains previously reported to be involved in interaction with DNA or chromatin. PMID: 23145062
    3. ALKBH4 represents an active Fe(II)/2OG-dependent decarboxylase and suggest that the cysteine cluster is involved in processes other than Fe co-ordination. PMID: 21166655
  • 亞細胞定位：
    Cytoplasm. Nucleus. Nucleus, nucleolus. Midbody.
  • 蛋白家族：
    AlkB family
  • 組織特異性：
    Widely expressed, with highest expression in pancreas, ovary and spleen.
  • 數據庫鏈接：

    HGNC: 21900

    OMIM: 613302

    KEGG: hsa:54784

    STRING: 9606.ENSP00000292566

    UniGene: Hs.658598