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  4. AK4 Recombinant Monoclonal Antibody

AK4 Recombinant Monoclonal Antibody

  • 中文名稱：
    AK4 Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA260365A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of adenylate kinase 4 expression in HepG2 cells using adenylate kinase 4 antibody. Green, isotype control; red, adenylate kinase 4.
    • Immunocytochemical staining of HepG2 cells with adenylate kinase 4 antibody. Nuclei were stained blue with DAPI; Adenylate kinase 4 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using adenylate kinase 4 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with adenylate kinase 4 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    AK4
  • 別名：
    AK4; Adenylate Kinase 4; AK3L1; AK3; Adenylate Kinase 4, Mitochondrial; Adenylate Kinase 3-Like 1; AK 4; GTP:AMP Phosphotransferase AK4, Mitochondrial; Adenylate Kinase Isoenzyme 4, Mitochondrial; Epididymis Secretory Sperm Binding Protein; Nucleoside-Triphosphate-Adenylate Kinase; Mitochondrial Adenylate Kinase-3; GTP:AMP Phosphotransferase AK4; ATP-AMP Transphosphorylase; Adenylate Kinase 3-Like; Adenylate Kinase 3; EC 2.7.4.10; EC 2.7.4.6; EC 2.7.4.3; EC 2.7.4; AK3L2
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human AK4 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    14A11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK. Plays a protective role in the cellular response to oxidative stress.
  • 基因功能參考文獻(xiàn)：
    1. Results found that AK4 was involved in hypoxia tolerance, resistance to anti-tumor drug, and the regulation of mitochondrial activity. PMID: 26980435
    2. a stress-protective function of AK4 PMID: 23474458
    3. Data indicate that patients with high adenylate kinase-4 (AK4) and low transcription factor ATF3 expression showed unfavorable outcomes compared with patients with low AK4 and high ATF3 expression. PMID: 23002211
    4. The AK4 cDNA was expressed in Escherichia coli and the substrate specificity and kinetic properties of the recombinant protein were characterized. PMID: 19766732
    5. To investigate the role of hinge IV, crystal structure of human adenylate kinase 4 (AK4) L171P mutant was determined. PMID: 19073142

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  • 亞細(xì)胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Adenylate kinase family, AK3 subfamily
  • 組織特異性：
    Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 363

    OMIM: 103030

    KEGG: hsa:205

    STRING: 9606.ENSP00000322175

    UniGene: Hs.10862