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  4. ACO2 Recombinant Monoclonal Antibody

ACO2 Recombinant Monoclonal Antibody

  • 中文名稱：
    ACO2 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA044311A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of aconitase 2 expression in HT-1080 cells using aconitase 2 antibody. Green, isotype control; red, aconitase 2.
    • Immunocytochemical staining of HepG2 cells with Aconitase 2 antibody. Nuclei were stained blue with DAPI; Aconitase 2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using aconitase 2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with aconitase 2 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ACO2
  • 別名：
    ACO2; Aconitase 2; Aconitate Hydratase, Mitochondrial; ACONM; Aconitase 2, Mitochondrial; Mitochondrial Aconitase; Citrate Hydro-Lyase; EC 4.2.1.3 ; Epididymis Secretory Sperm Binding Protein Li 284; HEL-S-284; Aconitase ; EC 4.2.1; ICRD; OCA8; OPA9
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human ACO2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    15A11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
  • 基因功能參考文獻：
    1. Aco2 activity correlated significantly with motor score, independence scale, and functional capacity of the Unified Huntington's Disease Rating Scale as well as disease duration. Our study provides a potential biomarker to assess the disease status of HD patients and PreHD carriers. PMID: 29160844
    2. Results suggest that ACO2 activity is reduced in peripheral lymphocytes of subjects with Alzheimer's disease and mild cognitive impairment and correlates with antioxidant protection PMID: 25322927
    3. Our study shows that autosomal recessive ACO2 mutations can cause either isolated or syndromic optic neuropathy. PMID: 25351951
    4. immunofluorescence staining localized ACO2 to the human sperm mid-piece. By immunoblotting, we demonstrated that the level of ACO2 protein in asthenozoospermic samples was significantly decreased compared with that in normal fertile men PMID: 24785945
    5. Ogg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity. PMID: 24429287
    6. Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells PMID: 23709747
    7. Gastric cancer patients with lower ACO2 expression have a shorter survival time than those with higher ACO2 expression. PMID: 23550275
    8. Homozygosity mapping followed by whole-exome sequencing disclosed a Ser112Arg mutation in ACO2. PMID: 22405087
    9. these results suggest that p53 downregulation of mACON gene expression in human prostate carcinoma cells may not occur through the putative consensus p53 response elements found within the mACON promoter. PMID: 20607720
    10. abolishes oxidant-induced apoptosis PMID: 19524665
    11. Lon protease selectively recognizes and degrades the oxidized, hydrophobic form of aconitase after mild oxidative modification, but that severe oxidation results in aconitase aggregation, which makes it a poor substrate for Lon. PMID: 12198491
    12. ACO2 is often deleted in colorectal cancer but is unlikely to be the true target of the deletions PMID: 12746427
    13. The m-aconitase promoter is contained in a 153-bp 5' fragment lacking a TATA or CAAT sequence. Sp1 binding to specific Sp1 site is needed for promoter activity. Other transcription factors are recruited through protein-protein interactions. PMID: 16598741
    14. Manganese acts as an antagonist of iron, disrupting the enzymatic activity and gene expression of mACON and citrate metabolism in the prostate. PMID: 16625280
    15. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia. PMID: 19405953
    16. This protein has been found differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19110265

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  • 相關疾病：
    Infantile cerebellar-retinal degeneration (ICRD); Optic atrophy 9 (OPA9)
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Aconitase/IPM isomerase family
  • 數據庫鏈接：

    HGNC: 118

    OMIM: 100850

    KEGG: hsa:50

    STRING: 9606.ENSP00000216254

    UniGene: Hs.643610