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  4. ABRAXAS1 Recombinant Monoclonal Antibody

ABRAXAS1 Recombinant Monoclonal Antibody

  • 中文名稱：
    ABRAXAS1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA975285A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of CCDC98 expression in HT-1080 cells using CCDC98 antibody. Green, isotype control; red, CCDC98.
    • Immunocytochemical staining of HT-1080 cells with CCDC98 antibody. Nuclei were stained blue with DAPI; CCDC98 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using CCDC98 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CCDC98 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ABRAXAS1
  • 別名：
    ABRAXAS1; Antibodyraxas 1, BRCA1 A Complex Subunit 2; ABRA1; FAM175A; CCDC98; Family With Sequence Similarity 175 Member A; BRCA1-A Complex Subunit Antibodyraxas 1; Coiled-Coil Domain Containing 98; Antibodyraxas Protein; FLJ13614; ABRAXAS; Family With Sequence Similarity 175, Member A; Coiled-Coil Domain-Containing Protein 98; Protein FAM175A
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human ABRAXAS1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    8E6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
  • 基因功能參考文獻：
    1. Our data also suggest how ataxia telangiectasia mutated (ATM)-dependent BRCA1 dimerization may stabilize self-association of the entire BRCA1-A complex. PMID: 28009280
    2. Results identified 16 novel rare variants in FAM175A but no significant difference in allele frequencies between cases and controls was observed which suggest no evidence that rare variants in ABRAXAS are associated with increased breast cancer risk in the population studied. PMID: 27270457
    3. Demonstrate a mechanism involving IR-induced phosphorylation and dimerization of the BRCT/Abraxas complex for regulating Abraxas-mediated recruitment of BRCA1 in response to IR. PMID: 26778126
    4. The recurrent Abraxas c.1082G>A mutation connects to breast cancer predisposition. PMID: 22357538
    5. low expression correlates with better response to chemotherapy and longer survival in patients with advanced non small-cell lung cancer PMID: 21529986
    6. CCDC98 is a BRCA1 binding partner that mediates BRCA1 function in response to DNA damage. PMID: 17643121
    7. CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response. PMID: 17643122
    8. Mutational analysis in 168 multiple-case breast/ovarian cancer families, negative for mutations in BRCA1 or BRCA2, suggests that CCDC98 does not play an important role as a high penetrance breast cancer susceptibility gene. PMID: 18270812
    9. examined RAP80 and Abraxas expression and their effect on treatment outcome in non-small-cell lung cancer PMID: 19415121

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  • 相關(guān)疾?。?/div>
    Breast cancer (BC)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    FAM175 family, Abraxas subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25829

    OMIM: 114480

    KEGG: hsa:84142

    STRING: 9606.ENSP00000369857

    UniGene: Hs.334772



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