国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

tolC Antibody

Rare Species
  • 中文名稱:
    tolC兔多克隆抗體
  • 貨號:
    CSB-PA355904XA01ENV
  • 規格:
    ¥880
  • 圖片:
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes:tolC Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 24 kDa
      Observed band size: 24 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Escherichia coli (strain K12) tolC Antibody Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    tolC Antibody
  • 別名:
    Outer membrane protein TolC (Multidrug efflux pump subunit TolC) (Outer membrane factor TolC) tolC colE1-i mtcB mukA refI toc weeA b3035 JW5503
  • 宿主:
    Rabbit
  • 反應種屬:
    Escherichia coli (strain K12)
  • 免疫原:
    Recombinant Escherichia coli (strain K12) tolC protein (97-268aa)
  • 免疫原種屬:
    Escherichia coli (strain K12)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.
  • 基因功能參考文獻:
    1. TolC, a potentially interesting pharmaceutical target can be addressed by small molecules, blocking the channel. Biophysical characterization of the binding processes will support future identification and optimisation of more potent TolC blockers in order to validate TolC as a pharmaceutical target. PMID: 28746830
    2. The authors report the near-atomic resolution cryoEM structures of the Escherichia coli AcrAB-TolC multidrug efflux pump in resting and drug transport states, revealing a quaternary structural switch that allosterically couples and synchronizes initial ligand binding with channel opening. PMID: 28355133
    3. A number of multi-drug efflux genes, particularly the central component TolC, show higher expression in antibiotic resistant Escherichia coli. PMID: 27105118
    4. Data suggest that outer membrane channel TolC plays an important role in extrusion of isoprenol and other medium-chain alcohols (CmOHs). PMID: 26563610
    5. Thus, tolC mutants grown in low iron conditions accumulate periplasmic enterobactin, which impairs bacterial morphology, possibly by sequestering iron and inhibiting an iron-dependent reaction involved in cell division or peptidoglycan synthesis. PMID: 24330203
    6. Interactions between TolC and AcrAB are highly dynamic and only a small fraction of TolC is utilized to support efflux activities. PMID: 23331412
    7. The TolC enhancement of extreme-acid survival includes Gad induction, but TolC-dependent growth rates below pH 6.5 do not involve Gad. PMID: 21541325
    8. These results indirectly suggest that TolC and YiaT proteins may play some role(s) in multidrug resistance. PMID: 20639525
    9. Inactivation of TolC triggers metabolic shutdown in E. coli cells grown in minimal glucose medium. PMID: 20545840
    10. essential for enterobactin export across the outer membrane PMID: 16166532
    11. The mechanism of tetracycline resistance was studied using expression studies in E. coli mutants that were defective in the tet(A) and the tolC proteins. PMID: 16687460
    12. Dada show that a combination of sbmA and tolC mutations appears to have additive effect, resulting in almost complete suppression of the phenotypic expression of Tn10 tetracycline resistance. PMID: 18083810
    13. Results describe two crystal structures of the Escherichia coli outer membrane protein TolC in its partially open state. PMID: 18406332
    14. TolC-dependent efflux system is involved in the exclusion of porphyrins in E. coli. PMID: 18641137
    15. The authors conclude that TolC plays an important role in L: -cysteine tolerance probably due to its export ability and that TolC overexpression is effective for L-cysteine production in E. coli. PMID: 18828007
    16. Data that TolC is involved in the efflux of certain cellular metabolites that accumulate during growth and trigger the upregulation of MarA, SoxS, and Rob, which in turn upregulate tolC and help rid the bacteria of these metabolites. PMID: 19502391

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell outer membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Outer membrane factor (OMF) (TC 1.B.17) family
  • 數據庫鏈接:


主站蜘蛛池模板: 邯郸县| 兖州市| 海丰县| 连州市| 焉耆| 璧山县| 冷水江市| 上饶市| 天门市| 普陀区| 玉环县| 葫芦岛市| 多伦县| 霍城县| 庆云县| 长乐市| 太白县| 讷河市| 盐城市| 蓬莱市| 新丰县| 当雄县| 榆林市| 松潘县| 陆良县| 青神县| 福泉市| 苏尼特左旗| 图木舒克市| 凤山县| 农安县| 泰顺县| 北流市| 南和县| 新郑市| 邮箱| 冷水江市| 龙井市| 莱西市| 宣恩县| 五台县|