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porin Antibody

  • 中文名稱：
    porin Antibody
  • 貨號：
    CSB-PA856714XA01DLU
  • 規格：
    ￥880
  • 圖片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes:porin Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 37.3 kDa
      Observed band size: 37.3 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Drosophila melanogaster (Fruit fly) porin Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    porin
  • 別名：
    Voltage-dependent anion-selective channel (DmVDAC) (Porin) porin POR-1 VDAC CG6647
  • 宿主：
    Rabbit
  • 反應種屬：
    Drosophila melanogaster (Fruit fly)
  • 免疫原：
    Recombinant Drosophila melanogaster (Fruit fly)porin protein (2-282aa)
  • 免疫原種屬：
    Drosophila melanogaster (Fruit fly)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. In depolarized mitochondria, acts downstream of park to promote mitophagy or prevent apoptosis; polyubiquitination by park promotes mitophagy, while monoubiquitination by park decreases mitochondrial calcium influx which ultimately inhibits apoptosis.
  • 基因功能參考文獻：
    1. The inhibition of porin phenocopies Parkinson disease phenotypes in Drosophila, while the overexpression of Buffy can counteract these phenotypes to improve the overall "healthspan" of the organism. PMID: 27881168
    2. Drosophila porin mutants have a role in mitochondrial dysfunction and disease PMID: 20110367
    3. identification of two PlacW insertions in the porin gene among a set of P-element insertions that have been mapped to the 32B3-4 region on the second chromosome PMID: 12207222
    4. Our data suggest that the PORIN protein is important in maintaining a photoreceptor response during prolonged stimulation. PMID: 17525991
    5. Porin isoform 1 is selectively targeted to follicular cells while Porin isoform 2 is present in mitochondria of the epithelial sheath cells of the ovariole. PMID: 18686020

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  • 亞細胞定位：
    Mitochondrion outer membrane.
  • 蛋白家族：
    Eukaryotic mitochondrial porin family
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG6647

    STRING: 7227.FBpp0079772

    UniGene: Dm.33362



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