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  4. kgp Antibody
  • 中文名稱：
    kgp兔多克隆抗體
  • 貨號：
    CSB-PA464342LA01EXZ
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: kgp antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 56 kDa
      Observed band size: 56 kDa
  • 其他：

產品詳情

  • 產品描述：

    The kgp antibody is designed to recognize the Porphyromonas gingivalis kgp protein. When a rabbit received an injection of the recombinant Porphyromonas gingivalis Lys-gingipain protein (229-594aa), an immune response occurred in the rabbit producing large amounts of antibodies against the kgp protein. The rabbit's blood was collected and isolated to get the anti-serum, which was purified by protein G to obtain the kgp polyclonal antibody (purity 95%+). This kgp antibody has accessed its specificity in ELISA and WB applications. Lys-gingipain is a Porphyromonas gingivalis-producing protease that plays a key role in viral pathogenicity.

    Lys-gingipain can cleave a wide range of host proteins, including immunoglobulins, complement proteins, and extracellular matrix proteins such as collagen and elastin, enabling them to invade and destroy host tissues leading to tissue damage and inflammation. In addition to its proteolytic activity, Lys-gingipain also has been shown to inhibit the host immune response, allowing P. gingivalis to establish a persistent infection and cause chronic periodontitis.

  • 產品名稱：
    Rabbit anti-Porphyromonas gingivalis kgp Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    kgp
  • 別名：
    kgp antibody; PGN_1728Lys-gingipain antibody; EC 3.4.22.47 antibody; Lysine-specific cysteine proteinase Kgp) [Cleaved into: Lys-gingipain catalytic subunit; 39 kDa adhesin; 15 kDa adhesin; 44 kDa adhesin] antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Porphyromonas gingivalis
  • 免疫原：
    Recombinant Porphyromonas gingivalis Lys-gingipain protein (229-594AA)
  • 免疫原種屬：
    Porphyromonas gingivalis
  • 標記方式：
    Non-conjugated

    本頁面中的產品，kgp Antibody (CSB-PA464342LA01EXZ)，的標記方式是Non-conjugated。對于kgp Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA464342LB01EXZ kgp Antibody, HRP conjugated ELISA
    FITC CSB-PA464342LC01EXZ kgp Antibody, FITC conjugated
    Biotin CSB-PA464342LD01EXZ kgp Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria.
  • 基因功能參考文獻：
    1. a significant fraction of SPINK6-sensitive proteases in healthy saliva and confirmed the ability of gingipains to inactivate SPINK6 under ex vivo conditions PMID: 27354280
  • 亞細胞定位：
    [Lys-gingipain catalytic subunit]: Secreted.
  • 蛋白家族：
    Peptidase C25 family
  • 數據庫鏈接：