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  4. Recombinant Mouse Dimethylaniline monooxygenase [N-oxide-forming] 3 (Fmo3)

Recombinant Mouse Dimethylaniline monooxygenase [N-oxide-forming] 3 (Fmo3)

  • 中文名稱：
    小鼠Fmo3重組蛋白
  • 貨號：
    008749MO
  • 規格：
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    Fmo3
  • 別名：
    Fmo3Dimethylaniline monooxygenase [N-oxide-forming] 3; EC 1.14.13.8; EC 1.14.14.73; Dimethylaniline oxidase 3; Hepatic flavin-containing monooxygenase 3; FMO 3; Trimethylamine monooxygenase; EC 1.14.13.148
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 應用說明：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 儲存條件：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
  • 基因功能參考文獻：
    1. Diabetes induced the expression of both Fmo3 and ICAM expression and possible vascular impairment through enteric dysbiosis. Diabetes-induced Fmo3 and ICAM expression could be reversed by pJNK inhibition or by correcting enteric dysbiosis. PMID: 29851956
    2. The suppression of FMO3 metabolism related to reversible S-nitrosyl modifications of iNOS-derived NO in type 1 allergic mice. PMID: 28760731
    3. knockdown or genetic deletion of the TMAO-producing enzyme flavin-containing monooxygenase 3 (FMO3) confers protection against obesity in mice. PMID: 28636934
    4. FMO3 can contribute to the regulation of glucose metabolism in the liver by reducing lipid-induced endoplasmic reticulum stress and the expression of PEPCK, independently of insulin signal transduction. PMID: 26886171
    5. FMO3 is increased in obese/insulin resistant male mice and necessary for expression of FoxO1. PMID: 25849138
    6. Fmo3 expression and function plays a role in protecting the liver from acetaminophen-induced toxicity. PMID: 24973094
    7. a major role for FMO3 in modulating glucose and lipid homeostasis PMID: 25378658
    8. Report temporal changes in hepatic Fmo3 gene expression under different conditions all known to cause hepatic oxidative stress. PMID: 25193093
    9. Report selective modulation of hepatic cytochrome P450 and flavin monooxygenase 3 expression during citrobacter rodentium infection in SCID mice. PMID: 22745333
    10. The functional activity of Fmo3 was determined. PMID: 17721934

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  • 亞細胞定位：
    Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    FMO family
  • 組織特異性：
    Liver.
  • 數據庫鏈接：