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ascl1a Antibody

Rare Species
  • 中文名稱：
    ascl1a兔多克隆抗體
  • 貨號：
    CSB-PA852654LA01DIL
  • 規格：
    ￥440
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) ascl1a Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ascl1a
  • 別名：
    ascl1a antibody; ash antibody; ash1a antibody; asha antibody; piaAchaete-scute homolog 1a antibody; Zash-1a antibody; Pituitary-absent protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Zebrafish
  • 免疫原：
    Recombinant Zebrafish Achaete-scute homolog 1a protein (1-196AA)
  • 免疫原種屬：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ascl1a Antibody (CSB-PA852654LA01DIL)，的標記方式是Non-conjugated。對于ascl1a Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA852654LB01DIL ascl1a Antibody, HRP conjugated ELISA
    FITC CSB-PA852654LC01DIL ascl1a Antibody, FITC conjugated
    Biotin CSB-PA852654LD01DIL ascl1a Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter. Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells.
  • 基因功能參考文獻：
    1. dlx1a/2a act downstream of ascl1a but upstream of dlx5a/dlx6a and gad1b to activate GABAergic specification PMID: 23747543
    2. bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine PMID: 23352790
    3. Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility PMID: 23353550
    4. Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt signaling inhibitor, Dkk, and induced expression of the Wnt ligand, Wnt4a. PMID: 21911394
    5. The Ascl1a regulates Muller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. PMID: 20935637
    6. Expressed in the postsembryonic zebrafish brain PMID: 12638130
    7. ash1a and ngn1 function in parallel redundant pathways to regulate neurogenesis downstream of flh PMID: 12702659
    8. Ascl1a might act downstream of diencephalic fibroblast growth factor 3 (Fgf3) signaling to mediate some of the effects of Fgf3 on the developing adenohypophysis PMID: 16481349
    9. Cellular correlates of proneural gene(ash1a) expression in the regenerating zebrafish retina. PMID: 17822581
    10. ascl1a is essential for retina regeneration: within 4 h after retinal injury, ascl1a is induced in Muller glia. PMID: 18234889

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    In the 24 hours embryo, expressed in the dorsal hindbrain in two bilaterally symmetrical lines of cells marking the boundary between the alar and basal plates, and ventrally in rhombomere 1 near the floor plate. Also expressed in embryonic adenohypophysis
  • 數據庫鏈接：

    KEGG: dre:30466

    STRING: 7955.ENSDARP00000056004

    UniGene: Dr.314