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VPS45 Antibody

  • 中文名稱：
    VPS45兔多克隆抗體
  • 貨號：
    CSB-PA950698
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA950698(VPS45 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    h-VPS45 antibody; H1 antibody; H1VPS45 antibody; HGNC:14579 antibody; hlVps45 antibody; Leucocyte vacuolar protein sorting 45 antibody; OTTHUMP00000014482 antibody; Vacuolar protein sorting 45 homolog (S. cerevisiae) antibody; Vacuolar protein sorting 45A (yeast homolog) antibody; Vacuolar protein sorting 45A antibody; Vacuolar protein sorting 45B (yeast) antibody; Vacuolar protein sorting-associated protein 45 antibody; Vps45 antibody; VPS45_HUMAN antibody; VPS45A antibody; VPS45B antibody; VPS54A antibody; VSP45 antibody; VSP45A antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human VPS45
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:30-1:150
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.
  • 基因功能參考文獻：
    1. A homozygous VPS45 p.E238K mutation is associated with severe congenital neutropenia with neurological impairment. PMID: 26358756
    2. we identified a Thr224Asn mutation in the VPS45 gene in infants from consanguineous families who suffered from life-threatening neutropenia. PMID: 23599270
    3. Defective endosomal intracellular protein trafficking due to biallelic mutations in VPS45 underlies a new immunodeficiency syndrome involving impaired neutrophil function. PMID: 23738510
    4. Data implicate hVps45 and Rabenosyn-5 in post early endosome transport, and suggest that their interaction serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes. PMID: 19931244
  • 相關疾病：
    Neutropenia, severe congenital 5, autosomal recessive (SCN5)
  • 亞細胞定位：
    Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
  • 蛋白家族：
    STXBP/unc-18/SEC1 family
  • 組織特異性：
    Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver.
  • 數據庫鏈接：

    HGNC: 14579

    OMIM: 610035

    KEGG: hsa:11311

    STRING: 9606.ENSP00000358126

    UniGene: Hs.443750



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