国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. UBE3C Antibody, FITC conjugated

UBE3C Antibody, FITC conjugated

  • 中文名稱：
    UBE3C兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA621871LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) UBE3C Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    HectH2 antibody; KIAA0010 antibody; KIAA10 antibody; Ube3c antibody; UBE3C_HUMAN antibody; Ubiquitin protein isopeptide ligase (E3) antibody; Ubiquitin protein ligase E3C antibody; Ubiquitin-protein ligase E3C antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin-protein ligase E3C protein (310-377AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
  • 基因功能參考文獻：
    1. miR-542-3p functioned as a tumor suppressor gene in regulating the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via targeting UBE3C. PMID: 28666208
    2. UBE3C promotes melanoma progression, possibly by inducing epithelial-mesenchymal transition in melanoma cells PMID: 26894856
    3. data reveal that high UBE3C expression contributes to glioma progression by ubiquitination and degradation of ANXA7, and thus presents a novel and promising target for glioma therapy. PMID: 26067607
    4. these observations suggest that UBE3C plays an important role in RCC development and progression, and UBE3C may be a novel target for prevention and treatment of ccRCC. PMID: 25658088
    5. UBE3C is a mutant candidate oncogene involved in tumor development and progression of hepatocellular carcinoma. PMID: 24425307
    6. knockdown renders cells more susceptible to the Hsp90 inhibitor 17-AAG, suggesting that UBE3C protects against the harmful accumulation of protein fragments arising from incompletely degraded proteasome substrates. PMID: 24158444
    7. Our findings provide evidence that variations in UBE3C are potent genetic markers of nasal polyps development in Korean asthmatics. PMID: 21881582
    8. negatively regulates type I interferon through ubiquitination of the transcription factors PMID: 21167755
    9. gene polymorphism is associated with the risk of Aspirin-intolerant asthma PMID: 20934631
    10. TIP120B is a specific substrate of KIAA10; both are highly expressed in human skeletal muscle, suggesting that KIAA10 may regulate TIP120B homeostasis specifically in this tissue. PMID: 12692129

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 16803

    OMIM: 614454

    KEGG: hsa:9690

    STRING: 9606.ENSP00000309198

    UniGene: Hs.118351



主站蜘蛛池模板： 琼结县| 揭阳市| 澄迈县| 龙川县| 长白| 偏关县| 改则县| 乳山市| 东台市| 博乐市| 礼泉县| 渑池县| 同心县| 曲沃县| 星子县| 靖远县| 武平县| 洛南县| 库车县| 新巴尔虎左旗| 海城市| 教育| 汕尾市| 通州市| 偃师市| 兴隆县| 额济纳旗| 屏南县| 乳山市| 凤台县| 新乐市| 呼图壁县| 天峻县| 成安县| 兰州市| 安福县| 黄陵县| 开阳县| 东丽区| 伊吾县| 永安市|