TRIM68 Antibody

產品詳情

Uniprot No.：

Q6AZZ1
基因名：

TRIM68
別名：

TRIM68 antibody; GC109 antibody; RNF137 antibody; SS56 antibody; E3 ubiquitin-protein ligase TRIM68 antibody; EC 2.3.2.27 antibody; RING finger protein 137 antibody; RING-type E3 ubiquitin transferase TRIM68 antibody; SSA protein SS-56 antibody; SS-56 antibody; Tripartite motif-containing protein 68 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human SS-56.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:40000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
基因功能參考文獻：
1. TRIM68 targets TFG, a novel regulator of IFN production, and in doing so turns off and limits type I IFN production in response to anti-viral detection systems PMID: 24999993
2. TRIM68 functions as a cofactor for AR-mediated transcription and is likely to be a novel diagnostic tool and a potentially therapeutic target for prostate cancer. PMID: 18451177
亞細胞定位：

Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus.
蛋白家族：

TRIM/RBCC family
組織特異性：

Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells.
數據庫鏈接：

HGNC: 21161

OMIM: 613184

KEGG: hsa:55128

STRING: 9606.ENSP00000300747

UniGene: Hs.523438