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TLE4 Antibody

  • 中文名稱：
    TLE4兔多克隆抗體
  • 貨號：
    CSB-PA004300
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of RAT-MUSCLE cells using TLE4 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TLE4
  • 別名：
    TLE4 antibody; GRG4 antibody; KIAA1261 antibody; Transducin-like enhancer protein 4 antibody; Grg-4 antibody; Groucho-related protein 4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TLE4.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression.
  • 基因功能參考文獻：
    1. the loss of TLE4 confers proliferative advantage to leukemic cells, simultaneous with an upregulation of a pro- inflammatory signature mediated through aberrant increases in Wnt signaling activity PMID: 27486062
    2. the results suggested that TLE4, a potential prognostic biomarker for colorectal cancer, plays an important role in the development and progression of human colorectal cancer. PMID: 26701208
    3. PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing. PMID: 25631048
    4. Groucho related gene Grg4 robustly activates the expression of a BMP reporter gene, as well as enhancing and sustaining the upregulation of the endogenous Id1 gene induced by BMP7. PMID: 24099773
    5. Displacing coactivators CREB-binding protein/p300 while promoting the recruitment of a corepressor, Grg4. PMID: 22927467
    6. Grg4 recruits the arginine methyltransferase PRMT5 to chromatin resulting in symmetric H4R3 dimethylation. PMID: 22169276
    7. germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein. PMID: 19893608
    8. Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors PMID: 17060451

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat Groucho/TLE family
  • 組織特異性：
    In all tissues examined, mostly in brain, and muscle.
  • 數據庫鏈接：

    HGNC: 11840

    OMIM: 605132

    KEGG: hsa:7091

    STRING: 9606.ENSP00000365735

    UniGene: Hs.444213



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