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SLC39A4 Antibody

  • 中文名稱：
    SLC39A4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA030205
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of Colo cells using ZIP4 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SLC39A4
  • 別名：
    SLC39A4; ZIP4; Zinc transporter ZIP4; Solute carrier family 39 member 4; Zrt- and Irt-like protein 4; ZIP-4
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ZIP4.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.
  • 基因功能參考文獻(xiàn)：
    1. Results showed decreased expression of Zn uptake transporters ZIP2 and ZIP4 on mRNA and protein level correlating with SHANK3 expression levels, and found reduced levels of ZIP4 protein co-localizing with SHANK3 at the plasma membrane. ZIP4 exists in a complex with SHANK3. Further results confirmed a link between enterocytic SHANK3, ZIP2 and ZIP4. PMID: 28345660
    2. Expression of zinc transporters ZIP4, ZIP14 and ZnT9 in hepatic carcinogenesis-An immunohistochemical study PMID: 29895370
    3. exosomal ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer. PMID: 30007115
    4. Structural insights of ZIP4 extracellular domain critical for optimal zinc transport have been uncovered. PMID: 27321477
    5. ZIP4 regulates human epidermal homeostasis in patients with acrodermatitis enteropathica. PMID: 27940220
    6. ZIP4 and intracellular zinc have essential roles in tumoral growth in oral squamous cell carcinoma PMID: 28017725
    7. Case Report: heterozygote mutation in SLC39A4 resulting in acrodermatitis enteropathica. PMID: 26351177
    8. Data sho that silencing of zinc transporter ZIP4 resulted in increased bone tissue mineral density, and restoration of bone strength. PMID: 26305676
    9. Studied the zinc binding properties of the large intracellular loop of hZIP4. PMID: 25882556
    10. The results described a previously uncharacterized role of ZIP4 in apoptosis resistance and elucidated a novel pathway through which ZIP4 regulates pancreatic cancer growth. PMID: 24553114
    11. In glioma tumors, high ZIP4 expression was significantly associated with higher grade. PMID: 25921144
    12. Developed is a structural model of ZIP4 by combining protein prediction methods with in situ experiments. Insight into the permeation pathway of ZIP4 is provided. PMID: 25971965
    13. SLC39A4 mutations have roles in zinc deficiency PMID: 25391167
    14. Both acrodermatitis mutations cause absence of the ZIP4 transporter cell surface expression and nearly absent zinc uptake. PMID: 24586184
    15. ZIP4 activates the zinc-dependent transcription factor CREB and requires this transcription factor to increase miR-373 expression through the regulation of its promoter. PMID: 23857777
    16. High ZIP4 expression is associated with glioma. PMID: 23595627
    17. resulkts indicate ZIP4 is the only zinc transporter that is significantly up-regulated in pancreatic cancer and might be the major zinc transporter that plays an important role in pancreatic cancer growth PMID: 23331012
    18. The results suggest that ZIP4 may be a tumor suppressor gene and down-regulation of ZIP4 may be a critical early event in the development of prostate carcinoma PMID: 21803616
    19. Expression of two Zn(2+) influx transporters, ZIP2 and ZIP4, is reduced as a function of retinal pigment epithelium age. PMID: 21603979
    20. Zinc, copper(II), and nickel can be transported by human ZIP4 when the cation concentration is in the micromolar range; nickel can bind to but is not transported by human ZIP4. PMID: 22242765
    21. The transporter ZIP4 is expressed along the entire gastrointestinal tract and acts as a major processor of dietary zinc PMID: 21462106
    22. GSPE and EGCG enhance the expression of cellular zinc importers ZIP4 (SLC39A4). PMID: 20471814
    23. Cell migration assays revealed that RNAi knockdown of Zip4 in Hepa cells depressed in vitro migration whereas forced over-expression in Hepa cells and MCF-7 cells enhanced in vitro migration PMID: 20957146
    24. Zinc can regulate the mRNA expression of ZIP4 in Caco2 cells. PMID: 16986515
    25. Overexpression of ZIP4 caused significantly increased expression of NRP-1, VEGF, MMP-2 and MMP-9 and is associated with angiogenesis, invasion and metastasis pathways in pancreatic cancer. PMID: 20023433
    26. ZIP4 overexpression causes increased IL-6 transcription through CREB, which in turn activates STAT3 and leads to increased cyclin D1 expression PMID: 20160059
    27. A novel member of a zinc transporter family, hZIP4, is defective in acrodermatitis enteropathica. PMID: 12032886
    28. SLC39A4 is centrally involved in the pathogenesis of acrodermatitis enteropathica. PMID: 12068297
    29. Three novel mutations, 1017ins53, which creates premature termination codon, and two mis-sense mutations, R95C and Q303H. PMID: 12787121
    30. temporal and spatial patterns of expression of the mouse ZIP1, 3, 4, and 5 genes in the developing intestine and the effects of maternal dietary zinc deficiency on these patterns of expression were examined PMID: 16682017
    31. ubiquitin-mediated degradation of the ZIP4 protein is critical for regulating zinc homeostasis in response to the upper tier of physiological zinc concentrations. PMID: 17202136
    32. therapeutic strategy whereby ZIP4 is targeted to control pancreatic cancer growth PMID: 18003899
    33. Acrodermatitis enteropathica is a rare autosomal recessive disorder caused by mutations in SLC39A4, which encodes the tissue-specific zinc transporter ZIP4. PMID: 18328205
    34. the clinical manifestations in three acrodermatitis enteropathica patients with a novel mutation PMID: 19416242
    35. results suggest that exon 9 in the SLC39A4 gene encompassing c.1438G should be screened first in the molecular diagnosis of Japanese patients with Acrodermatitis Enteropathic. PMID: 19416256
    36. Knocking down ZIP4 by short hairpin RNA might be a novel treatment strategy for pancreatic cancers with ZIP4 overexpression. PMID: 19755388

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  • 相關(guān)疾病：
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.
  • 蛋白家族：
    ZIP transporter (TC 2.A.5) family
  • 組織特異性：
    Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17129

    OMIM: 201100

    KEGG: hsa:55630

    STRING: 9606.ENSP00000301305

    UniGene: Hs.521934