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SLC35C1 Antibody

  • 中文名稱：
    SLC35C1兔多克隆抗體
  • 貨號：
    CSB-PA839285LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA839285LA01HU diluted at 1:400 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SLC35C1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC35C1
  • 別名：
    SLC35C1 antibody; FUCT1GDP-fucose transporter 1 antibody; Solute carrier family 35 member C1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human GDP-fucose transporter 1 protein (287-364AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，SLC35C1 Antibody (CSB-PA839285LA01HU)，的標記方式是Non-conjugated。對于SLC35C1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA839285LB01HU SLC35C1 Antibody, HRP conjugated ELISA
    FITC CSB-PA839285LC01HU SLC35C1 Antibody, FITC conjugated
    Biotin CSB-PA839285LD01HU SLC35C1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.
  • 基因功能參考文獻：
    1. two Turkish siblings with a novel mutation in GDP-fucose transporter and features of congenital disorder of glycosylation IIc PMID: 25239688
    2. Fx enzyme and GDP-L-Fuc Tr overexpression in the tumur tissue of colorectal cancer (CRC) patients suggests that GDP-L-Fuc transport to the Golgi apparatus may be an important factor associated with increased alpha(1,6)fucosylation in CRC. PMID: 23730929
    3. In the rare LAD-II disease, the fucosylation of selectin ligands is disturbed, caused by mutations in SLC35C1, the gene that encodes a GDP-fucose transporter of the Golgi system. (Review) PMID: 22134107
    4. the conserved glycine residues at positions 180 and 277 of SLC35C1 have significant impacts on lectin binding PMID: 22492235
    5. In the GDP-fucose transporter a new single nucleotide deletion produced an open-reading frame shift & polypeptide truncation. Overexpression of the mutant protein in fibroblasts did not rescue fucosylation. The deletion ablated transporter activity. PMID: 12406889
    6. Leukocyte adhesion deficiency II patients display dual defect in functoin ang Golgi expression of FUCT1. PMID: 16455955
    7. the upregulation of GDP-Fuc Tr plays a pivotal role in increased fucosylation in hepatocellular carcinoma PMID: 17884843

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  • 相關疾病：
    Congenital disorder of glycosylation 2C (CDG2C)
  • 亞細胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    TPT transporter family, SLC35C subfamily
  • 數據庫鏈接：

    HGNC: 20197

    OMIM: 266265

    KEGG: hsa:55343

    STRING: 9606.ENSP00000313318

    UniGene: Hs.12211