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SCN7A Antibody

  • 中文名稱：
    SCN7A兔多克隆抗體
  • 貨號：
    CSB-PA040294
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SCN7A
  • 別名：
    SCN7A antibody; SCN6A antibody; Sodium channel protein type 7 subunit alpha antibody; Putative voltage-gated sodium channel subunit alpha Nax antibody; Sodium channel protein cardiac and skeletal muscle subunit alpha antibody; Sodium channel protein type VII subunit alpha antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Na+ CP type VIIα.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
  • 基因功能參考文獻(xiàn)：
    1. The authors demonstrated that the sodium channel Nax functions as a sodium sensor. With increased extracellular sodium, Nax up-regulates prostasin, which results in activation of the sodium channel ENaC. PMID: 26537257
    2. SNP rs7565062 of SCN7A was significantly associated with essential hypertension in a Northern Han Chinese population PMID: 25393565
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium channel (TC 1.A.1.10) family, SCN7A subfamily
  • 組織特異性：
    Heart and uterus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10594

    OMIM: 182392

    KEGG: hsa:6332

    STRING: 9606.ENSP00000386796

    UniGene: Hs.596087