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RMND1 Antibody

  • 中文名稱：
    RMND1兔多克隆抗體
  • 貨號：
    CSB-PA882123LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: MCF7 whole cell lysate(30μg), HepG2 whole cell lysate(30μg), THP-1 whole cell lysate(30μg)
      All lanes: RMND1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 52,28,24 kDa
      Observed band size: 52 kDa
      Exposure time: 120s
    • IHC image of CSB-PA882123LA01HU diluted at 1:50 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
    • IHC image of CSB-PA882123LA01HU diluted at 1:50 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
    • IHC image of CSB-PA882123LA01HU diluted at 1:50 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RMND1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RMND1
  • 別名：
    bA351K16 antibody; bA351K16.3 antibody; C6orf96 antibody; chromosome 6 open reading frame 96 antibody; FLJ20627 antibody; MGC117362 antibody; MGC149570 antibody; MGC882602 antibody; required for meiotic nuclear division 1 homolog (S. cerevisiae) antibody; Required for meiotic nuclear division protein 1 homolog antibody; Rmnd1 antibody; RMND1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Required for meiotic nuclear division protein 1 homolog protein (35-160AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，RMND1 Antibody (CSB-PA882123LA01HU)，的標記方式是Non-conjugated。對于RMND1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA882123LB01HU RMND1 Antibody, HRP conjugated ELISA
    FITC CSB-PA882123LC01HU RMND1 Antibody, FITC conjugated
    Biotin CSB-PA882123LD01HU RMND1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome.
  • 基因功能參考文獻：
    1. Hearing impairment and renal failure are associated with RMND1 mutations. PMID: 26395190
    2. Expression of ESR1, RMND1 and CCDC170 associated with variants in separate enhancer elements predisposing breast cancer. [meta-analysis] PMID: 26928228
    3. Results demonstrate that the RMND1 complex is necessary for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome. PMID: 23022098
    4. The RMND1 mutation caused haploinsufficiency that was rescued by overexpression of the wild-type transcript in mutant fibroblasts; this overexpression increased the levels and activities of mitochondrial respiratory-chain proteins. PMID: 23022099
  • 相關疾病：
    Combined oxidative phosphorylation deficiency 11 (COXPD11)
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    RMD1/sif2 family
  • 數據庫鏈接：

    HGNC: 21176

    OMIM: 614917

    KEGG: hsa:55005

    STRING: 9606.ENSP00000356272

    UniGene: Hs.486835